1350549-36-8

Basic information

• Product Name: trans-4-(6-(butylamino)-3-(4-(morpholinosulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)cyclohexanol
• CAS NO: 1350549-36-8
• Molecular Weight: 514.649
• Mol File: 1350549-36-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: trans-4-(6-(butylamino)-3-(4-(morpholinosulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)cyclohexanol(CAS DataBase Reference)
• NIST Chemistry Reference: trans-4-(6-(butylamino)-3-(4-(morpholinosulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)cyclohexanol(1350549-36-8)
• EPA Substance Registry System: trans-4-(6-(butylamino)-3-(4-(morpholinosulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)cyclohexanol(1350549-36-8)

Safety Data

• Hazardous Substances Data: 1350549-36-8(Hazardous Substances Data)

Usage

Uses

UNC 1025 acts as a potent Mer inhibitor used in the treatment of cancer and oncogenesis.

Upstream product

• 1306829-95-7 3-bromo-6-(methylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidine 
• 1401222-64-7 4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)sulfonyl)morpholine 
• 1350550-51-4 3-bromo-N-butyl-1H-pyrazolo[3,4-d]pyrimidin-6-amine 

Relevant articles and documents

UNC1062, a new and potent Mer inhibitor

Abnormal activation of Mer kinase has been implicated in the oncogenesis of many human cancers including acute lymphoblastic and myeloid leukemia, non-small cell lung cancer, and glioblastoma. We have discovered a new family of small molecule Mer inhibitors, pyrazolopyrimidine sulfonamides, that potently inhibit the kinase activity of Mer. Importantly, these compounds do not demonstrate significant hERG activity in the PatchXpress assay. Through structure-activity relationship studies, 35 (UNC1062) was identified as a potent (IC50 = 1.1 nM) and selective Mer inhibitor. When applied to live tumor cells, UNC1062 inhibited Mer phosphorylation and colony formation in soft agar. Given the potential of Mer as a therapeutic target, UNC1062 is a promising candidate for further drug development.