135074-01-0Relevant articles and documents
AN ALTERNATIVE SYNTHESIS OF 2-BENZYLOXY-6-HYDROXYMETHYL-3-ISOBUTYL-5-METHOXYPYRAZINE 4-OXIDE, A KEY INTERMEDIATE FOR SYNTHESIS OF OPC-15161
Hashizume, Satoshi,Sano, Atsunori,Oka, Masahisa
, p. 1581 - 1588 (2007/10/02)
2-Benzyloxy-6-hydroxymethyl-3-isobutyl-5-methoxypyrazine 4-oxide (5e), a key intermediate for synthesis of OPC-15161 (1a) having an inhibitory activity against superoxide anion generation, was prepared from 5-amino-2-benzyloxy-3-isobutyl-6-methoxycarbonylpyrazine 4-oxide (5b) by 3-step reaction.