1350916-22-1

Basic information

• Product Name: 6-(N-(2,4-dichlorophenyl)-N-methylsulfamoyl)-1-hydroxy-1H-indole-2-carboxylic acid
• Synonyms: 6-(N-(2,4-dichlorophenyl)-N-methylsulfamoyl)-1-hydroxy-1H-indole-2-carboxylic acid
• CAS NO: 1350916-22-1
• Molecular Weight: 415.254
• Mol File: 1350916-22-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-(N-(2,4-dichlorophenyl)-N-methylsulfamoyl)-1-hydroxy-1H-indole-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(N-(2,4-dichlorophenyl)-N-methylsulfamoyl)-1-hydroxy-1H-indole-2-carboxylic acid(1350916-22-1)
• EPA Substance Registry System: 6-(N-(2,4-dichlorophenyl)-N-methylsulfamoyl)-1-hydroxy-1H-indole-2-carboxylic acid(1350916-22-1)

Safety Data

• Hazardous Substances Data: 1350916-22-1(Hazardous Substances Data)

Upstream product

• 616-83-1 4-methyl-3-nitrobenzenesulfonyl chloride 
• 35113-88-3 N-methyl-2,4-dichloro-aniline 
• 1350916-11-8 methyl 6-(N-(2,4-dichlorophenyl)-N-methylsulfamoyl)-1-hydroxy-1H-indole-2-carboxylate 
• 1350916-03-8 N-(2,4-dichlorophenyl)-N,4-dimethyl-3-nitrobenzenesulfonamide 

Relevant articles and documents

Synthesis of sulfonamide-containing N-hydroxyindole-2-carboxylates as inhibitors of human lactate dehydrogenase-isoform 5

N-Hydroxyindole-2-carboxylates possessing sulfonamide-substituents at either position 5 or 6 were designed and synthesized. The inhibitory activities of these compounds against isoforms 1 and 5 of human lactate dehydrogenase were analysed, and Ki values of the most efficient inhibitors were determined by standard enzyme kinetic studies. Some of these compounds displayed state-of-the-art inhibitory potencies against isoform 5 (Ki values as low as 5.6 μM) and behaved as competitive inhibitors versus both the substrate and the cofactor.