1350969-09-3Relevant articles and documents
Identification of a methoxynaphthalene scaffold as a core replacement in quinolizidinone amide M1 positive allosteric modulators
Kuduk, Scott D.,Di Marco, Christina N.,Saffold, Jonathan R.,Ray, William J.,Ma, Lei,Wittmann, Marion,Koeplinger, Kenneth A.,Thompson, Charles D.,Hartman, George D.,Bilodeau, Mark T.,Beshore, Douglas C.
, p. 1417 - 1420 (2014)
A series of methoxynaphthalene amides were prepared and evaluated as alternatives to quinolizidinone amide M1 positive allosteric modulators. A methoxy group was optimal for M1 activity and addressed key P-gp issues present in the aforementioned quinolizidinone amide series.
