135106-52-4

Basic information

• Product Name: 5-METHOXYQUINAZOLIN-4-OL
• Synonyms: 5-METHOXYQUINAZOLIN-4-OL;5-Methoxyquinazolin-4(3H)-one;5-Methoxy-3H-quinazolin-4-one
• CAS NO: 135106-52-4
• Molecular Formula: C₉H₈N₂O₂
• Molecular Weight: 176.17
• Mol File: 135106-52-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 5-METHOXYQUINAZOLIN-4-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHOXYQUINAZOLIN-4-OL(135106-52-4)
• EPA Substance Registry System: 5-METHOXYQUINAZOLIN-4-OL(135106-52-4)

Safety Data

• Hazardous Substances Data: 135106-52-4(Hazardous Substances Data)

Usage

General Description

5-Methoxyquinazolin-4-ol is a chemical compound belonging to the category of quinazolinone derivatives. It is a heterocyclic compound with a quinazoline core structure and a methoxy group attached to the fourth position of the ring. This chemical may have potential pharmaceutical applications due to its structural features, particularly in the field of medicinal chemistry. Quinazolinone derivatives have been studied for their potential biological activities, including anticancer, antibacterial, antiviral, and antifungal properties. Further research and studies on the biological and pharmacological activities of 5-Methoxyquinazolin-4-ol may reveal its potential as a drug candidate or lead to the development of new therapeutic agents.

Upstream product

• 875245-80-0 2-formylamino-6-methoxy-benzoic acid amide 
• 54166-96-0 methyl 2-amino-6-methoxybenzoate 
• 463-52-5 formamidine 
• 436-72-6 5-fluoroquinazolin-4(3H)-one 
• 124-41-4 sodium methylate 
• 1591-38-4 2-amino-6-methoxybenzamide 

Downstream Products

• 179246-14-1 4-chloro-5-methoxyquinazoline 
• 379228-40-7 4-[(2-chloro-5-methoxyphenyl)amino]quinazolin-5-ol 
• 733017-02-2 5-methoxy-4-(3'-nitrophenyl)quinazoline 
• 733017-05-5 5-hydroxy-4-(3'-nitrophenyl)quinazoline 
• 733017-04-4 5-hydroxy-4-(4'-trifluoromethylphenyl)quinazoline 
• 733017-01-1 5-methoxy-4-(4'-trifluoromethylphenyl)quinazoline 
• 733017-08-8 4-(3'-nitrophenyl)-5-trifluoromethylsulfonyloxyquinazoline 
• 733017-07-7 4-(4'-trifluoromethylphenyl)-5-trifluoromethylsulfonyloxyquinazoline 

Relevant articles and documents

4- (IH-INDAZOL-S-YL-AMINO)-QUINAZOLINE COMPOUNDS AS ERBB RECEPTOR TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF CANCER

A quinazoline derivative of the Formula I: wherein the substituents are as defined in the text for use in the production of an anti proliferative effect which effect is produced alone or in part by inhibiting erbB2 receptor tyrosine kinase in a warm blood

N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy] -5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor

Src family kinases (SFKs) are nonreceptor tyrosine kinases that are reported to be critical for cancer progression. We report here a novel subseries of C-5-substituted anilinoquinazolines that display high affinity and specificity for the tyrosine kinase domain of the c-Src and Abl enzymes. These compounds exhibit high selectivity for SFKs over a panel of recombinant protein kinases, excellent pharmacokinetics, and in vivo activity following oral dosing. N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine (AZD0530) inhibits c-Src and Abl enzymes at low nanomolar concentrations and is highly selective over a range of kinases. AZD0530 displays excellent pharmacokinetic parameters in animal preclinically and in man (t1/2 = 40 h). AZD0530 is a potent inhibitor of tumor growth in a c-Src-transfected 3T3-fibroblast xenograft model in vivo and led to a significant increase in survival in a highly aggressive, orthotopic model of human pancreatic cancer when dosed orally once daily. AZD0530 is currently undergoing clinical evaluation in man.