135112-28-6 Usage
Description
FMOC-NVA-OH, also known as 9-fluorenylmethoxycarbonyl-norvaline, is a synthetic amino acid derivative used in the field of peptide chemistry. It is a white powder with specific chemical properties that make it suitable for various applications in the pharmaceutical and biotechnology industries.
Uses
Used in Pharmaceutical Industry:
FMOC-NVA-OH is used as a building block for the synthesis of polypeptides, which are essential components of various biologically active molecules, including drugs and therapeutic agents. Its application in the preparation of polypeptide drug conjugates allows for the development of targeted drug delivery systems, enhancing the efficacy and specificity of treatments.
Used in Biotechnology Industry:
FMOC-NVA-OH is used as a tumor-targeting polypeptide, which can be incorporated into drug conjugates to improve the selectivity and effectiveness of cancer treatments. By targeting specific tumor cells, these conjugates can minimize side effects and reduce damage to healthy cells, making them a promising approach in the fight against cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 135112-28-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,5,1,1 and 2 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 135112-28:
(8*1)+(7*3)+(6*5)+(5*1)+(4*1)+(3*2)+(2*2)+(1*8)=86
86 % 10 = 6
So 135112-28-6 is a valid CAS Registry Number.
135112-28-6Relevant articles and documents
Determination of Chemical and Enantiomeric Purity of α-Amino Acids and their Methyl Esters as N-Fluorenylmethoxycarbonyl Derivatives Using Amylose-derived Chiral Stationary Phases
Islam, Md. Fokhrul,Adhikari, Suraj,Paik, Man-Jeong,Lee, Wonjae
, p. 332 - 338 (2019/04/13)
Liquid chromatographic enantiomer separation and simultaneous determination of chemical and enantiomeric purity of α-amino acids and their methyl esters as N-fluorenylmethoxycarbonyl (FMOC) derivatives was performed on three covalently bonded type chiral stationary phases (CSPs) derived from amylose derivatives. The enantiomer separation of α-amino acid esters as N-FMOC derivatives was better than that of the corresponding acids, especially for CSP 1 and 2. Chemical impurities as the corresponding racemic acids present in several commercially available racemic amino acid methyl esters were observed to be 0.49–17.50%. Enantiomeric impurities of several commercially available L-amino acid methyl esters were found to be 0.03–0.58%, whereas chemical impurities as the corresponding racemic acids present in the same analytes were found to be 0.13–13.62%. This developed analytical method will be useful for the determination of chemical and enantiomeric purity of α-amino acids and/or esters as N-FMOC derivatives using amylose-derived CSPs.