1351445-87-8

Basic information

• Product Name: 2-methoxy-3-cyano-4-(2,6-dichlorophenyl)-5,6-dihydropyrido[2,3-a]carbazole
• CAS NO: 1351445-87-8
• Molecular Weight: 420.298
• Mol File: 1351445-87-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-methoxy-3-cyano-4-(2,6-dichlorophenyl)-5,6-dihydropyrido[2,3-a]carbazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methoxy-3-cyano-4-(2,6-dichlorophenyl)-5,6-dihydropyrido[2,3-a]carbazole(1351445-87-8)
• EPA Substance Registry System: 2-methoxy-3-cyano-4-(2,6-dichlorophenyl)-5,6-dihydropyrido[2,3-a]carbazole(1351445-87-8)

Safety Data

• Hazardous Substances Data: 1351445-87-8(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 109-77-3 malononitrile 
• 3456-99-3 1-oxo-2,3,4,9-tetrahydrocarbazole 
• 1687-48-5 cyclohexane 1,2-dione monophenylhydrazone 

Relevant articles and documents

Selective synthesis and X-ray structural analysis of a pyridocarbazole derivative

Pyridocarbazole possesses many biological activities such as antimicrobial and antitumor properties. It also serves as a selective inhibitor for cyclic GMP phosphodiesterase (cGMP-PDE) enzyme. Since it is very similar to ellipticine and olivacine, its derivatives are endowed with DNA intercalating properties. One of the pyridocarbazoles, MCDDC, has been synthesized and its stereochemistry has been proven by X-ray crystallographic study. The crystal belongs to the monoclinic space group, P21/a, with cell parameters a = 11.771(3) A, b = 14.557(3) A, c = 11.869(1) A and β = 101.80(2)°. According to the X-ray structure, the entire MCDDC molecule adopts a planar conformation except for the dichlorophenyl ring, which is almost orthogonal to the pyridine ring. Molecules are tightly bound by the N-H???N type hydrogen bonds and weak C-H???π interactions also help in packing stabilization. Graphical Abstract: One of the pyridocarbazoles, MCDDC, has been synthesized and its selectivity has been proved by X-ray crystallographic study. [Figure not available: see fulltext.]