13515-07-6

Basic information

• Product Name: 5,6-diphenyl-pyrazine-2-carboxylic acid
• Synonyms: 5,6-diphenyl-pyrazine-2-carboxylic acid
• CAS NO: 13515-07-6
• Molecular Weight: 276.294
• Mol File: 13515-07-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5,6-diphenyl-pyrazine-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-diphenyl-pyrazine-2-carboxylic acid(13515-07-6)
• EPA Substance Registry System: 5,6-diphenyl-pyrazine-2-carboxylic acid(13515-07-6)

Safety Data

• Hazardous Substances Data: 13515-07-6(Hazardous Substances Data)

Downstream Products

• 1588-89-2 2,3-diphenylpyrazine 

Relevant articles and documents

Scaffold hopping, synthesis and structure-activity relationships of 5,6-diaryl-pyrazine-2-amide derivatives: A novel series of CB1 receptor antagonists

A scaffold hopping approach has been exploited to design a novel class of cannabinoid (CB1) receptor antagonists for the treatment of obesity. On the basis of shape-complementarity and synthetic feasibility the central fragment, a methylpyrazole, in Rimonabant was replaced by a pyrazine. The synthesis and CB1 antagonistic activities of a new series of 5,6-diaryl-pyrazine-2-amide derivatives are described. Several compounds showed antagonist potency below 10 nM for the CB1 receptor.