13515-95-2

Basic information

• Product Name: methyl 2,6-diaminohexanoate hydrochloride
• Synonyms: methyl 2,6-diaminohexanoate hydrochloride;(S)-Methyl 2,6-diaminohexanoate hydrochloride
• CAS NO: 13515-95-2
• Molecular Formula: C₇H₁₇N₂O₂*Cl
• Molecular Weight: 196.67508
• Mol File: 13515-95-2.mol
• Article Data: 31

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: methyl 2,6-diaminohexanoate hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2,6-diaminohexanoate hydrochloride(13515-95-2)
• EPA Substance Registry System: methyl 2,6-diaminohexanoate hydrochloride(13515-95-2)

Safety Data

• Hazardous Substances Data: 13515-95-2(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 56-87-1 L-lysine 
• 657-27-2 L-Lysine hydrochloride 
• 77-76-9 2,2-dimethoxy-propane 
• 75-77-4 chloro-trimethyl-silane 
• 70-53-1 2,6-diaminohexanoic acid hydrochloride 
• 26124-78-7 (S)-α-lysine hydrochloride 
• 13734-28-6 Boc-Lys-OH 
• 17929-90-7 3-aminoazepan-2-one 

Downstream Products

• 943590-99-6 C₂₃H₂₉N₃O₅ 
• 139091-49-9 (3R)-AH(Nps)IBA-L-Lys 
• 139091-49-9 (2S,3S)-AH(Nps)IBA-L-Lys 
• 139091-49-9 (2R,3S)-AH(Nps)IBA-L-Lys 
• 943443-86-5 C₂₂H₃₃N₄O₆ 
• 1197285-78-1 (S)-2-{(2R,3R,Z)-1-[(S)-2-benzamido-6-guanidinohexanoyl]-4-ethylidene-3-methylpyrrolidine-2-carboxamido}-4-methyl-pentanoic acid 
• 1337555-97-1 (S)-2-{(2R,3S,Z)-1-[(S)-2-benzamido-6-guanidinohexanoyl]-4-ethylidene-3-methylpyrrolidine-2-carboxamido}-4-methyl-pentanoic acid 
• 1337556-02-1 (S)-2-{(2S,3S,Z)-1-[(S)-2-benzamido-6-guanidinohexanoyl]-4-ethylidene-3-methylpyrrolidine-2-carboxamido}-4-methyl-pentanoic acid 
• 1360186-70-4 (S)-methyl 2-((2S,3R,Z)-1-((S)-2-benzamido-6-((Z)-2,3-bis(tert-butoxycarbonyl)guanidino)hexanoyl)-4-ethylidene-3-methylpyrrolidine-2-carboxamido)-4-methylpentanoate 
• 1360186-73-7 (S)-methyl 2-((2S,3S,Z)-1-((S)-2-benzamido-6-((Z)-2,3-bis(tert-butoxycarbonyl)guanidino)hexanoyl)-4-ethylidene-3-methylpyrrolidine-2-carboxamido)-4-methyl pentanoate 
• 1360186-75-9 (S)-methyl 2-((2R,3S,Z)-1-((S)-2-benzamido-6-((Z)-2,3-bis(tert-butoxycarbonyl)guanidino)hexanoyl)-4-ethylidene-3-methylpyrrolidine-2-carboxamido)-4-methylpentanoate 
• 1360186-79-3 (S)-methyl 2-((2R,3R,Z)-1-((S)-2-benzamido-6-((Z)-2,3-bis(tert-butoxycarbonyl)guanidino)hexanoyl)-4-ethylidene-3-methylpyrrolidine-2-carboxamido)-4-methylpentanoate 
• 1197285-64-5 (S,Z)-methyl 2-benzamido-6-(2,3-bis(tert-butoxycarbonyl)guanidino)hexanoate 
• 1197285-65-6 (S,Z)-2-benzamido-6-(2,3-bis(tert-butoxycarbonyl)guanidino)hexanoic acid 

Relevant articles and documents

Synthesis, characterization and topical application of novel bifunctional peptide metallodendrimer

Present research work focuses on the synthesis of lower generation bifunctional peptide metallodendrimer followed by its characterization using IR, Mass and NMR (1H and 13C) and finally exploring it for treating acne and wounds. Metallodendrimer was formulated into Tamarind Seed Polysaccharide (TSP) based hydrogel at 7% w/w concentration and analyzed for its properties of spreadability and bioadhesion. Testing of in-vitro antibacterial activity, sterility, in-vivo wound healing efficacy and stability studies followed the formulation development stage. The explored peptide metallodendrimer is a complex of second generation lysine dendrimers and zinc, exhibiting antibacterial activity against Propionibacterium acne, Staphylococcus epidermidis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. In-vivo wound healing studies in comparison with marketed product indicated significant performance by metallodendrimer with respect to percent re-epithelization and wound contracture. The results were supported by concurrent improvement in various histopathological parameters such as cellularity, granulation, epithelization, vascular density, collagen staining intensity with less number of average mast cells and absence of scar formation. A bifunctional peptide metallodendrimer based platform technology was fabricated and duly evaluated for potential activities.

Novel chiral derivatizing agents for 1H NMR determination of enantiomeric purities of carboxylic acids

(S)-4-(3-Aminopyrrolidin-1-yl)coumarin (1), (S)-4-(3-aminopiperidin-1-yl)coumarin (4), and (S)-4-(3-aminoazepan-1-yl)coumarin (7), prepared from 4-chlorocoumarin and (S)-pyrrolidin-3-amine, (S)-piperidin-3-amine, and (S)-azepan-3-amine, respectively, were proven to be versatile and reliable 1H NMR optical purity determination agents for chiral carboxylic acids.

Supramolecular self-assembly of chiral polyimides driven by repeat units and end groups

Pyromellitic diimides (PMDIs) are effective building blocks for the construction of supramolecular systems but are infrequently used in comparison with other electron-deficient aromatic systems. We report PMDI-based chiral polyimides that form polymeric supramolecular systems with unique self-assembly features that show time-dependent spectroscopic behaviour. Extensive investigations revealed the driving forces for the self-assembly of the polyimides. One is the complementary aromatic π-π stacking between electron-accepting PMDI and electron-donating phenyl ring in the polymer backbones, and another is the hydrogen bonding interactions of the end groups. The self-assembly is readily disrupted by guest molecules with strong associations with the PMDI and the end groups. The introduction of flexible arylether diimides into the PMDI-based copolymer backbones and the sequence of PMDIs and arylether diimides in the copolymer backbones significantly influence the self-assembly of the polyimides. The results elucidate the mechanisms of polymeric self-assembly of chiral polyimides, providing important information for the development of materials based on polymeric supramolecular systems with properties and functions regulated by composition, sequence and end groups.