135197-44-3

Basic information

• Product Name: 3-Cyclohexyl-2-formyl-propionitrile
• Synonyms: 3-Cyclohexyl-2-formyl-propionitrile
• CAS NO: 135197-44-3
• Molecular Weight: 165.235
• Mol File: 135197-44-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-Cyclohexyl-2-formyl-propionitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Cyclohexyl-2-formyl-propionitrile(135197-44-3)
• EPA Substance Registry System: 3-Cyclohexyl-2-formyl-propionitrile(135197-44-3)

Safety Data

• Hazardous Substances Data: 135197-44-3(Hazardous Substances Data)

Upstream product

• 41010-09-7 3-cyclohexylpropionitrile 
• 109-94-4 formic acid ethyl ester 
• 192653-35-3 2-Cyano-3-cyclohexylpropenal 
• 192653-31-9 (E)-3-Cyclohexyl-2-dimethoxymethyl-acrylonitrile 
• 2043-61-0 cyclohexanecarbaldehyde 

Downstream Products

• 192653-54-6 methyl 3-({[(methoxycarbonyl)amino][(methoxycarbonyl)imino]methyl}amino)-4-(cyclohexylmethyl)-1H-pyrrole-2-carboxylate 
• 135197-17-0 2-amino-7-(cyclohexylmethyl)-4-oxo-3H,5H-pyrrolo[3,2-d]pyrimidine 
• 135197-47-6 methyl 3-amino-4-(cyclohexylmethyl)-1H-pyrrole-2-carboxylate 

Relevant articles and documents

Process for the preparation of 9-deazaguanine derivatives

Derivatives of 9-deazaguanine are prepared by reacting an aldehyde or ketone with a dialkylaminomalonate to form the corresponding enamine. The enamine is then reacted with a base to form a cyclic pyrrole. The cyclic pyrrole is reacted with an urea compound or a derivative of carbamimidoic acid to provide a protected guanidino compound. The guanidino is converted to the desired 9-deazaguanine derivative by reacting with trifluoracetic acid or with an alkoxide or hydroxide followed by neutralization with an acid.

Structure-based design of inhibitors of purine nucleoside phosphorylase. 2. 9-Alicyclic and 9-heteroalicyclic derivatives of 9-deazaguanine

Alicyclic and heteroalicyclic derivatives of 9-deazaguanine (2-amino-1,5- dihydro-4H-pyrrolo[3,2-d][pyrimidin-4-one) are, with one exception, potent inhibitors of purine nucleoside phosphorylase (PNP) equaling the corresponding 9-arylmethyl derivatives pr