1352085-91-6

Basic information

• Product Name: 3-{2-ethyl-4-[2-(5-methyl-2-p-tolyloxazol-4-yl)ethoxy]phenyl}propanoic acid
• CAS NO: 1352085-91-6
• Molecular Weight: 393.483
• Mol File: 1352085-91-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-{2-ethyl-4-[2-(5-methyl-2-p-tolyloxazol-4-yl)ethoxy]phenyl}propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-{2-ethyl-4-[2-(5-methyl-2-p-tolyloxazol-4-yl)ethoxy]phenyl}propanoic acid(1352085-91-6)
• EPA Substance Registry System: 3-{2-ethyl-4-[2-(5-methyl-2-p-tolyloxazol-4-yl)ethoxy]phenyl}propanoic acid(1352085-91-6)

Safety Data

• Hazardous Substances Data: 1352085-91-6(Hazardous Substances Data)

Upstream product

• 1352085-98-3 3-bromo-4-carbonylpentyl benzoate 
• 1383439-81-3 C₂₅H₂₉NO₄ 
• 477541-32-5 methanesulfonic acid 2-(5-methyl-2-p-tolyloxazol-4-yl)ethyl ester 
• 619-55-6 para-methylbenzamide 
• 157169-68-1 2-(2-(4-methylphenyl)-5-methyloxazol-4-yl)acetic acid methyl ester 
• 105983-77-5 methyl 4-bromo-3-oxopentanoate 
• 157169-71-6 2-[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]ethanol 
• 30414-53-0 methyl propanoyl acetate 
• 1071-73-4 5-Hydroxy-2-pentanone 
• 1383439-54-0 C₂₀H₁₉NO₃ 
• 1352086-01-1 3-amine-4-carbonylpentyl benzoate 
• 1352085-99-4 3-azido-4-carbonylpentyl benzoate 

Relevant articles and documents

COMPOUNDS HAVING ACTIVATING EFFECT ON SUBTYPES OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS AND ITS PREPARATION METHOD AND USES

Phenyl propanoic acid compounds having activating effect on peroxisome proliferator-activated receptors (PPARα,δ,γ) and a preparation method and uses thereof are provided in the present invention. The compounds can be used for treating or preventing diseases associated with peroxisome proliferator-activated receptors (PPARα,δ,γ).

Design and synthesis of 3-(2-ethyl-4-{2-[2-(4-fluorophenyl)- 5-methyloxazol-4-yl]ethoxy}phenyl)propanoic acid: A novel triple-acting PPARα, -γ, and -δ Agonist

The design and synthesis of triple-acting PPARα, -γ, and -δ agonist 3-(2-ethyl-4-{2-[2-(4-fluorophenyl)-5-methyloxazol-4-yl]- ethoxy}phenyl)propanoic acid (1a) is described. The compound possesses a potent triple-acting PPARα, -γ, and -δ agonist profile with an EC50 of 0.029, 0.013, and 0.029 μM, respectively. The synthetic route, involving the synthesis of oxazole rings as the key step, starts from commercially available 3-oxopentanoic acid methyl ester and 3- hydroxyacetophenone to afford the target compound 1 with an overall yield of 32%.