1352212-89-5Relevant articles and documents
Design and synthesis of simplified taxol analogs based on the T-Taxol bioactive conformation
Zhao, Jielu,Bane, Susan,Snyder, James P.,Hu, Haipeng,Mukherjee, Kamalika,Slebodnick, Carla,Kingston, David G.I.
, p. 7664 - 7678 (2012/01/05)
A series of compounds designed to adopt a conformation similar to the tubulin-binding T-Taxol conformation of the anticancer drug paclitaxel has been synthesized. Both the internally bridged analogs 37-39, 41 and the open-chain analogs 27-29 and 43 were prepared. The bridged analogs 37-39 and 41 were synthesized by Grubbs' metatheses of compounds 30-32 and 33, which, in turn, were prepared by coupling β-lactams 24-26 with alcohols 22 and 23. Both the bridged and the open-chain analogs showed moderate to good cytotoxicity.