1352614-15-3Relevant articles and documents
Enantioselective Cascade Reaction of α-Cyano Ketones and Isatylidene Malononitriles: Asymmetric Construction of Spiro[4H-pyran-oxindoles]
Xie, Jin,Xing, Wei-Long,Sha, Feng,Wu, Xin-Yan
, p. 3983 - 3992 (2016)
α-Cyano ketones have been employed for the first time as Michael donors in the construction of chiral spiro compounds. By using only 2 mol-% of a chiral multifunctional organocatalyst, chiral spiro[4H-pyran-oxindole] derivatives were prepared in yields of 97–99 % with enantioselectivities of 76–97 % ee. This method provides a new approach to the synthesis of chiral spirocyclic oxindoles.