135285-81-3 Usage
Description
2-[[(4-Aminophenyl)sulfonyl]amino]-4-thiazoleacetic acid is a chemical compound that belongs to the class of thiazoleacetic acid derivatives. It features a thiazole ring fused to an acetic acid moiety, with a sulfonamide group and an aniline group attached to the thiazole ring. 2-[[(4-Aminophenyl)sulfonyl]amino]-4-thiazoleacetic acid possesses potential pharmacological properties due to its ability to interact with biological molecules and has been studied for its antibacterial and antifungal activities. It also serves as a building block in the synthesis of other organic compounds, indicating its potential applications in medicinal chemistry and drug discovery.
Uses
Used in Pharmaceutical Industry:
2-[[(4-Aminophenyl)sulfonyl]amino]-4-thiazoleacetic acid is used as a pharmaceutical intermediate for the development of new drugs, leveraging its ability to interact with biological molecules and its demonstrated antibacterial and antifungal activities.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2-[[(4-Aminophenyl)sulfonyl]amino]-4-thiazoleacetic acid is used as a key building block in the synthesis of complex organic compounds, contributing to the discovery and design of novel therapeutic agents.
Used in Drug Discovery:
2-[[(4-Aminophenyl)sulfonyl]amino]-4-thiazoleacetic acid plays a role in drug discovery as a compound with potential pharmacological properties, which can be further optimized and developed into effective treatments for various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 135285-81-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,5,2,8 and 5 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 135285-81:
(8*1)+(7*3)+(6*5)+(5*2)+(4*8)+(3*5)+(2*8)+(1*1)=133
133 % 10 = 3
So 135285-81-3 is a valid CAS Registry Number.
InChI:InChI=1/C11H11N3O4S2/c12-7-1-3-9(4-2-7)20(17,18)14-11-13-8(6-19-11)5-10(15)16/h1-4,6H,5,12H2,(H,13,14)(H,15,16)
135285-81-3Relevant articles and documents
Hapten synthesis and development of polyclonal antibody-based multi-sulfonamide immunoassays
Zhang, Hongyan,Duan, Zhenjuan,Wang, Lei,Zhang, Yan,Wang, Shuo
, p. 4499 - 4505 (2007/10/03)
This paper reports the synthesis of five sulfonamide derivatives, the production of broad-specificity polyclonal antibodies for immunoassay of sulfonamides, and the analysis of milk samples by developed assay. The three-step synthesis procedure reported in most of the literature was adopted and modified in this study. In the procedure, the purification of the intermediate was avoided and the time of synthesis was shortened from >20 to 6-9 h with improved yields. This method is generally applicable to the synthesis of haptens containing the common structure of sulfonamides. Three haptens were coupled to keyhole limpet hemocyanin, and polyclonal antibodies were obtained from rabbits immunized with these conjugates. Using the antibodies obtained, from one of these was developed an enzyme-linked immunosorbent assay (ELISA) based on the competition between free sulfonamides and the hapten-horseradish peroxidase (HRP) conjugates. The hapten-HRP conjugate giving the best competitive results and 11 structurally different sulfonamides showed 50% inhibition at concentrations of -1. After removal of the protein with acetone, milk samples were analyzed by ELISA directly; a matrix effect could be avoided when a 1:20 dilution with phosphate-buffered saline was used, and 104-131% recoveries of spiked samples were obtained. The developed immunoassay is suitable to determine sulfisozole, sulfathiazole, sulfameter, sulfamethoxypyridazine, sulfapyridine, and sulfamethizole below the maximum residue limit in milk (100 ng mL-1 of total sulfonamides) rapidly and reliably.