1352943-58-8

Basic information

• Product Name: 2-isobutoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile
• Synonyms: 2-isobutoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile
• CAS NO: 1352943-58-8
• Molecular Weight: 301.193
• Mol File: 1352943-58-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-isobutoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-isobutoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile(1352943-58-8)
• EPA Substance Registry System: 2-isobutoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile(1352943-58-8)

Safety Data

• Hazardous Substances Data: 1352943-58-8(Hazardous Substances Data)

Upstream product

• 876918-26-2 5-bromo-2-isobutoxy-benzonitrile 
• 73183-34-3 bis(pinacol)diborane 
• 40530-18-5 5-bromo-2-hydroxybenzonitrile 

Downstream Products

• 1415309-89-5 C₁₅H₁₆N₄O₂ 
• 1415309-89-5 5-(2-amino-6-oxo-1,6-dihydropyrimidin-4-yl)-2-isobutoxybenzonitrile 
• 1574394-61-8 5-(2-amino-5-chloro-6-oxo-1,6-dihydropyrimidin-4-yl)2-isobutoxybenzonitrile 
• 1419747-05-9 2-amino-6-[3-cyano-4-(isobutoxy) phenyl]pyrimidine 
• 1419747-01-5 C₁₆H₁₇N₃O₂ 
• 1419746-97-6 C₁₅H₁₅N₃O₂ 
• 1419746-93-2 C₁₆H₁₇N₅O₂ 
• 1419746-89-6 C₁₆H₁₆N₄O₃ 

Relevant articles and documents

HTS followed by NMR based counterscreening. Discovery and optimization of pyrimidones as reversible and competitive inhibitors of xanthine oxidase

The identification of novel, non-purine based inhibitors of xanthine oxidase is described. After a high-throughput screening campaign, an NMR based counterscreen was used to distinguish actives, which interact with XO in a reversible manner, from assay artefacts. This approach identified pyrimidone 1 as a reversible and competitive inhibitor with good lead-like properties. A hit to lead campaign gave compound 41, a nanomolar inhibitor of hXO with efficacy in the hyperuricemic rat model after oral dosing.

COMPOSITIONS AND THERAPEUTIC USES OF IKK-RELATED KINASE EPSILON AND TANKBINDING KINASE 1 INHIBITORS

The invention relates to compounds, pharmaceutical compositions and medicaments comprising such compounds, and the use of these compounds, compositions, and medicaments in methods of treating diseases and disorders.