1353012-00-6

Basic information

• Product Name: Azido-peg4-pfp ester
• Synonyms: Azido-peg4-pfp ester;Azido-PEG5-PFP ester;N3-PEG4-PFP
• CAS NO: 1353012-00-6
• Molecular Formula: C17H20F5N3O6
• Molecular Weight: 457.349216
• Mol File: 1353012-00-6.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Solubility: Soluble in DMSO, DCM, DMF
• CAS DataBase Reference: Azido-peg4-pfp ester(CAS DataBase Reference)
• NIST Chemistry Reference: Azido-peg4-pfp ester(1353012-00-6)
• EPA Substance Registry System: Azido-peg4-pfp ester(1353012-00-6)

Safety Data

• Hazardous Substances Data: 1353012-00-6(Hazardous Substances Data)

Usage

Description

Azido-PEG4-PFP ester is a versatile click reagent that features an azide group and a PFP (pentafluorophenyl) moiety. This reagent is designed to facilitate Click Chemistry, a set of efficient and selective reactions that allow for the rapid and reliable assembly of complex molecules. The azide group in Azido-PEG4-PFP ester enables the formation of stable triazole linkages with alkyne-containing molecules, while the PFP ester can be used to label primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. Compared to NHS (N-hydroxysuccinimide) ester, PFP ester is more stable, making it a preferred choice for certain applications. Additionally, the hydrophilic PEG (polyethylene glycol) spacer enhances the water solubility of the reagent, which is beneficial for its use in various biological and chemical processes.

Uses

Used in Bioconjugation:
Azido-PEG4-PFP ester is used as a bioconjugation agent for the selective labeling of primary amines in proteins, amine-modified oligonucleotides, and other amine-containing molecules. The stable triazole linkage formed through Click Chemistry ensures that the labeled molecules maintain their structural integrity and function.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Azido-PEG4-PFP ester is used as a component in the development of drug delivery systems. The hydrophilic PEG spacer and stable PFP ester linkage contribute to the improved solubility and stability of drug molecules, enhancing their bioavailability and therapeutic efficacy.
Used in Diagnostics:
Azido-PEG4-PFP ester is employed as a diagnostic tool in the development of imaging agents and probes. The reagent's ability to form stable triazole linkages with alkyne-containing molecules allows for the creation of highly specific and sensitive diagnostic agents that can be used in various imaging techniques, such as fluorescence imaging and magnetic resonance imaging (MRI).
Used in Research and Development:
In the field of research and development, Azido-PEG4-PFP ester is utilized as a key component in the synthesis of novel bioactive molecules and the study of biological processes. The reagent's compatibility with Click Chemistry enables the rapid and reliable assembly of complex molecular structures, facilitating the discovery of new therapeutic agents and the elucidation of biological mechanisms.
Used in Material Science:
In material science, Azido-PEG4-PFP ester is used as a building block for the development of functional materials with tailored properties. The reagent's ability to form stable triazole linkages and its hydrophilic PEG spacer make it an attractive candidate for the creation of materials with enhanced stability, solubility, and biocompatibility.