1353639-64-1Relevant articles and documents
Synthesis and cytotoxicity evaluation of phosphorylated derivatives of ribavirin
Rao, Valasani Koteswara,Reddy, Sanapalli Subba,Babu, Kilaru Raveendra,Kumar, Kuntrapakam Hema,Ghosh, Sunil Kumar,Raju, Chamarthi Naga
, p. 952 - 959 (2012/02/15)
Novel phosphorylated derivatives of ribavirin 5-16 were synthesized by the reaction of 4-nitrophenyl phosphorodichloridate with various amino acid esters in the presence of triethylamine in dry tetrahydrofuran through the intermediates 3. On further reaction of 3 with ribavirin in THF and pyridine in the presence of TEA afforded the title compounds 5-16. Their structures were characterized by IR, 1H, 13C, 31P NMR and mass spectral analyses. All the title compounds were found to exhibit potent in vitro anticancer activity against MCF-7 breast cancer cell lines.