1353748-56-7

Basic information

• Product Name: C₁₇H₂₀N₂O₅
• CAS NO: 1353748-56-7
• Molecular Weight: 332.356
• Mol File: 1353748-56-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₇H₂₀N₂O₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₂₀N₂O₅(1353748-56-7)
• EPA Substance Registry System: C₁₇H₂₀N₂O₅(1353748-56-7)

Safety Data

• Hazardous Substances Data: 1353748-56-7(Hazardous Substances Data)

Upstream product

• 108-69-0 3,5-dimethylaminoaniline 
• 25233-52-7 N-(3,5-dimethylphenyl)-3-oxobutanamide 
• 33797-51-2 eschenmoser's salt 
• 14337-43-0 ethyl 2-chloro-2-(hydroxyimino)acetate 

Relevant articles and documents

Expedient synthesis of a 72-membered isoxazolino-β-ketoamide library by a 2·3-component reaction

An efficient 2·3-component reaction (2·3CR; a 2-component reaction followed, in one pot, by a3-component reaction) is presented for the synthesis of isoxazolino-β-ketoamides. This 2·3CR proceeds by (i) a Meldrum's acid-generated acyl ketene, which is trapped by an amine to form a β-ketoamide intermediate in a 2CR followed, in one pot, by (ii) a Mannich reaction followed by elimination of dimethyl amine·HCl to generate an α,β-unsaturated β-ketoamide dipolarophile that reacts in a nitrile oxide 1,3-dipolar cycloaddition reaction. This one-pot 2·3CR process delivers the targeted isoxazolino-β-ketoamide product. A total of 72 compounds are presented, all of which have been submitted to the NIH Molecular Libraries Small Molecule Repository for high-throughput biological screening.