135391-21-8Relevant articles and documents
Methods of producing pantothenic acid derivative and its starting materials for producing the same
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, (2008/06/13)
A method of producing a pantothenic acid derivative of formula (I): STR1 wherein each of R1 and R2 is different, and is a branched aliphatic hydrocarbon group having 3 to 5 carbon atoms, or a phenyl group; or a straight chain aliphat
Pantothenic acid derivatives
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, (2008/06/13)
Compounds represented by general formula (I) below wherein R1 and R2, which are the same or different, each represent a hydrogen atom or a protective group for a hydroxyl group;, R3 represents a saturated or unsaturated, linear, branched or cyclic, monovalent C5~C25-aliphatic hydrocarbon group which may be substituted with an aro-matic group, or a group of formula where R4 represents a saturated or unsaturated, linear, branched or cyclic, monovalent C5~C25--aliphatic hydrocarbon group which may be sub-stituted with an aromatic group, and, R5 represents a hydrogen atom, or a saturated or unsaturated, linear, branched or cyclic, monovalent hydrocarbon group which may be substituted with an aromatic group; Q represents (a) a group of formula -X1-A-Y1-,where A represents a saturated or unsaturated, linear, branched or cyclic divalent C2~C16--aliphatic hydrocarbon group which may be sub-stituted with an aromatic group, a divalent aromatic hydrocarbon group or a divalent aro-matic heterocyclic group;, one of X1 and Y1 represents and the other represents -O-, -S- or in which R6 and R7 each represent a hydrogen atom or a lower alkyl group; (b) a group of formula -X2-(CH2)l-Y2-,where one of X2 and Y2 represents a group of formula and the other represents -O-, -S- or represents a 4~7--membered, divalent nitrogen-containing aromatic heterocyclic group, and R6 has the same meaning as defined above, and l is 0, 1 or 2; or (c) a group of formula where m is 2 or 3;, n is an integer of from 1 to 4. The compounds have excellent inhibitory activ-ity against acyl Co A-cholesterol-acyltransferase.