1353999-02-6Relevant articles and documents
Palladium-mediated cell-surface labeling
Spicer, Christopher D.,Triemer, Therese,Davis, Benjamin G.
, p. 800 - 803 (2012)
Benign C-C bond formation at various sites in cell-surface channels has been achieved through Suzuki-Miyaura coupling of genetically positioned unnatural amino acids containing aryl halide side chains. This enabled site-selective cell surface manipulation of Escherichia coli; the phosphine-free catalyst caused no cell death at required Pd loadings, suggesting future in vivo application of catalytic metal-mediated bond formation in more complex organisms.