1354044-23-7

Basic information

• Product Name: 1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazole-3-carboximidamide
• Synonyms: 1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazole-3-carboximidamide
• CAS NO: 1354044-23-7
• Molecular Weight: 285.281
• Mol File: 1354044-23-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazole-3-carboximidamide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazole-3-carboximidamide(1354044-23-7)
• EPA Substance Registry System: 1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazole-3-carboximidamide(1354044-23-7)

Safety Data

• Hazardous Substances Data: 1354044-23-7(Hazardous Substances Data)

Upstream product

• 1446353-53-2 C₁₄H₁₀FN₃O₃ 
• 1446353-66-7 C₁₄H₉FN₄O 
• 1354044-05-5 1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazole-3-carboximidamide hydrochloride 
• 88511-37-9 1-(isoxazol-3-yl)ethan-1-one 

Downstream Products

• 1354041-91-0 5-fluoro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidin-4(3H)-one 
• 1354042-03-7 C₁₈H₁₅FN₆O₂ 
• 1354041-90-9 2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidin-4-ol 
• 1446358-76-4 3-(5-fluoro-6-oxo-1,6-dihydropyrimidin-2-yl)-1-(2-fluorobenzyl)-1H-pyrazole-5-carbonitrile 
• 1446358-78-6 C₁₇H₁₃FN₆O₂ 
• 1446358-79-7 C₂₂H₁₉FN₆O₃ 
• 1446358-80-0 C₁₇H₁₀BrClFN₅O 
• 1446359-92-7 4-chloro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-5-sulfonyl chloride 
• 1446358-81-1 4-chloro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-5-sulfonyl chloride 
• 1446358-82-2 4-chloro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-5-sulfonyl chloride 
• 1446358-83-3 4-chloro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-5-sulfonyl chloride 
• 1446358-84-4 4-chloro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-5-sulfonyl chloride 
• 1446358-85-5 C₂₄H₁₇BrFN₅O₂ 
• 1446358-86-6 C₂₅H₁₉BrFN₅O₃ 

Relevant articles and documents

PYRAZOLE DERIVATIVES AS SGC STIMULATORS

There are described imidazole and pyrazole derivatives which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.

Discovery of IWP-051, a Novel Orally Bioavailable sGC Stimulator with Once-Daily Dosing Potential in Humans

In recent years, soluble guanylate cyclase (sGC, EC 4.6.1.2) has emerged as an attractive therapeutic target for treating cardiovascular diseases and diseases associated with fibrosis and end-organ failure. Herein, we describe our design and synthesis of