13547-76-7Relevant articles and documents
Palladium-catalyzed dehydrogenative β-arylation of simple saturated carbonyls by aryl halides
Gandeepan, Parthasarathy,Rajamalli,Cheng, Chien-Hong
, p. 4485 - 4489 (2015/01/09)
(Chemical Equation Presented) A versatile palladium-catalyzed synthesis of highly substituted α,β-unsaturated carbonyl compounds has been developed. In contrast to the known Heck-type coupling reaction of unsaturated carbonyl compounds with aryl halides, the present methodology allows the use of stable and readily available saturated carbonyl compounds as the alkene source. In addition, the reaction proceeds well with low catalyst loadings and does not require any expensive metal oxidants or ligands. A variety of saturated aldehydes, ketones, and esters are compatible for the reaction with aryl halides under the developed reaction conditions to afford α,β-unsaturated carbonyl compounds in good to excellent yields. A possible reaction mechanism involves a palladium-catalyzed dehydrogenation followed by Heck-type cross couplings.
Practical metal-free synthesis of chalcone derivatives via a tandem cross-dehydrogenative-coupling/elimination reaction
Wei, Yu,Tang, Jinghua,Cong, Xuefeng,Zeng, Xiaoming
supporting information, p. 3165 - 3169 (2013/11/06)
Metal-free synthesis of chalcone derivatives through a tandem cross-dehydrogenative-coupling/elimination reaction is described. A simple and inexpensive ammonium persulfate salt enables the reaction between ketones and benzylamines to proceed with high stereoselectivity and good functional group compatibility.
PREPARATION OF 1-PHENYL-3-METHYLISOQUINOLINE AND ITS DERIVATIVES FROM OXIMES OF 3-ARYL-2-METHYL-1-PHENYL-2-PROPEN-1-ONES
Zielinski, Wojciech
, p. 2209 - 2215 (2007/10/02)
1-Phenyl-3-methylisoquinoline and its derivatives substituted in 5, 6 or 7 positions (4) have been obtained by cyclization reaction of N-α-methylstyrylbenzimidoyl chloride (3) produced by Beckmann rearrangement by appopriate oximes (2) in the presence of PCl5.