135490-84-5

Basic information

• Product Name: 1-phenyl-2-(thiophen-3-yl)ethane-1,2-dione
• Synonyms: 1-phenyl-2-(thiophen-3-yl)ethane-1,2-dione
• CAS NO: 135490-84-5
• Molecular Weight: 216.26
• Mol File: 135490-84-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-phenyl-2-(thiophen-3-yl)ethane-1,2-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenyl-2-(thiophen-3-yl)ethane-1,2-dione(135490-84-5)
• EPA Substance Registry System: 1-phenyl-2-(thiophen-3-yl)ethane-1,2-dione(135490-84-5)

Safety Data

• Hazardous Substances Data: 135490-84-5(Hazardous Substances Data)

Usage

Physical state

Yellow crystalline solid

Molecular weight

244.31 g/mol

Use in organic synthesis

Building block for various pharmaceuticals and agrochemicals

Use in research and development

Reagent in the synthesis of complex organic molecules

Potential biological activities

Under investigation for use as a therapeutic agent

Additional research needed

To understand its full range of properties and potential applications.

Upstream product

• 131423-29-5 1-phenyl-2-(3-thienyl)ethyne 
• 1589-82-8 phenylmagnesium bromide 
• 146767-38-6 2-phenyl-1-(thiophen-3-yl)ethanone 
• 36634-80-7 1-(3-thienyl)phenethyl alcohol 
• 498-62-4 3-thiophene carboxaldehyde 
• 67237-53-0 3-ethynylthiophene 
• 100-63-0 phenylhydrazine 
• 536-74-3 phenylacetylene 
• 100-52-7 benzaldehyde 

Downstream Products

• 3193-25-7 2-hydroxy-2-phenyl-2-(thiophen-3-yl)acetic acid 

Relevant articles and documents

Synthetic method of 1,2-diketone compound

The invention discloses a synthetic method of a 1,2-diketone compound. The method comprises the following steps: under room temperature, an alkyne compound is taken as a raw material, a Ru/C is takenas a catalyst, an oxidizing agent and sulfuric acid are added, acetonitrile and water with a volume ratio being 1-5:1 are taken as solvents, the materials are completely reacted at the temperature of20-30 DEG C, and a reaction solution is subjected to separating and purifying to obtain the 1,2-diketone compound. The method has the advantages that operation is simple, reaction time is short, yield(achieving to 100%) is high, substrate universality is wide, water and acetonitrile are taken as the primary solvents (the solvent acetonitrile is easily recovered and used), and a heterogeneous phase catalyst Ru/C is easily recovered. The synthetic method of the 1,2-diketone compound accords with green chemistry characteristic, and is very suitable for industrialization.

An unusual chemoselective oxidation strategy by an unprecedented exploration of an electrophilic center of DMSO: A new facet to classical DMSO oxidation

A conceptually new dimethyl sulfoxide (DMSO) based oxidation process without the use of any activator has been demonstrated for the oxidation of active methylenes and benzhydrols. The developed protocol utilizes the electrophilic center of DMSO for oxidation, which was unexplored before. Mechanistic investigation has confirmed that the source of oxygen is DMSO.

THE REACTION OF SOME SUBSTITUTED BENZILS AND HETEROCYCLIC ANALOGS WITH CHLOROSULFONIC ACID

The chlorosulfonation of a number of unsymmetrical benzils gave substituted benzofurans.Ring closure is dependent upon the electronic character of the substituent groups and can be controlled by electronwithdrawing groups.The reaction of the 2-thienyl ana