1355026-34-4

Basic information

• Product Name: C₁₄H₁₃Cl₂N₃O₃
• CAS NO: 1355026-34-4
• Molecular Weight: 342.182
• Mol File: 1355026-34-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₄H₁₃Cl₂N₃O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₄H₁₃Cl₂N₃O₃(1355026-34-4)
• EPA Substance Registry System: C₁₄H₁₃Cl₂N₃O₃(1355026-34-4)

Safety Data

• Hazardous Substances Data: 1355026-34-4(Hazardous Substances Data)

Upstream product

• 163083-48-5 6-methyl-2-nitropyridin-3-yl trifluoromethanesulfonate 
• 1199-28-6 2-(2,4-dichlorophenoxy)ethylamine 

Relevant articles and documents

Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P4-R) agonists

High affinity and selective small molecule agonists of the S1P4 receptor (S1P4-R) may have significant therapeutic utility in diverse disease areas including autoimmune diseases, viral infections and thrombocytopenia. A high-throughput screening (HTS) of the Molecular Libraries-Small Molecule Repository library identified 3-(2-(2,4- dichlorophenoxy)ethoxy)-6-methyl-2-nitropyridine as a moderately potent and selective S1P4-R hit agonist. Design, synthesis and systematic structure-activity relationships study of the HTS-derived hit led to the development of novel potent S1P4-R agonists exquisitely selective over the remaining S1P1-3,5-Rs family members. Remarkably, the molecules herein reported provide novel pharmacological tools to decipher the biological function and assess the therapeutic utility of the S1P4-R.