135604-63-6

Basic information

• Product Name: 1-(pyrrolidinyl-2-on-1-yl)-1-triethylsilylethane
• CAS NO: 135604-63-6
• Molecular Weight: 227.422
• Mol File: 135604-63-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(pyrrolidinyl-2-on-1-yl)-1-triethylsilylethane(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(pyrrolidinyl-2-on-1-yl)-1-triethylsilylethane(135604-63-6)
• EPA Substance Registry System: 1-(pyrrolidinyl-2-on-1-yl)-1-triethylsilylethane(135604-63-6)

Safety Data

• Hazardous Substances Data: 135604-63-6(Hazardous Substances Data)

Upstream product

• 617-86-7 triethylsilane 
• 88-12-0 1-ethenyl-2-pyrrolidinone 

Relevant articles and documents

Regioselective Rh(I)-catalyzed sequential hydrosilylation toward the assembly of silicon-based peptidomimetic analogues

A highly regioselective Rh(I)-catalyzed hydrosilylation of enamides is presented. This mild protocol allows access to a wide variety of different arylsilanes with substitution at the β-position of the enamide and functionalization on the alkyl chain tethered to the silane. This protocol is extended to include a sequential one-pot hydrosilylation. Using diphenylsilane as the appendage point, hydrosilylation of a protected allyl alcohol followed by hydrosilylation of an enamide generates a complex organosilane in one step. This highly convergent strategy to synthesize these functionalized systems now provides a way for the rapid assembly of a diverse collection of silane-based peptidomimetic analogues.