135605-97-9Relevant articles and documents
Ortho-dithiol reactive treatment probe for drug release monitoring and preparation method of ortho-dithiol reactive treatment probe
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Paragraph 0014; 0016, (2021/07/28)
The invention discloses an ortho-dithiol reactive treatment probe for drug release monitoring and a preparation method of the ortho-dithiol reactive treatment probe. The structure of a probe compound is shown as a formula I in the specification. A probe m
COMPOUND HAVING BENZO SEVEN-MEMBERED RING STRUCTURE, PREPARATION METHOD THEREFOR, AND USE THEREOF
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Paragraph 0173-0174, (2021/12/14)
The present invention relates to a compound having a benzo seven-membered ring structure, and a preparation method therefor, and use thereof. The compound has a structure as represented by formula (I). Provided is use of the compound having the structure and prepared with the preparation method of the present invention, enantiomers, diastereomers, racemates and mixtures thereof of the compound, as well as chemically acceptable salts, crystalline hydrates and solvent mixtures of the compound and the enantiomers, diastereomers, racemates and mixtures thereof of the compound in the preparation of drugs for treating BET Bromodomain BRD4 activity or expression level related diseases.
METHOD OF PREPARING (3R,5R)-7-(2-(4-FLUOROPHENYL)-5-ISOPROPYL-3-PHENYL-4-((4-HYDROXYMETHYLPHENYLAMINO)CARBONYL)-PYRROL-1-YL)-3,5-DIHYDROXY-HEPTANOIC ACID HEMI CALCIUM SALT, INTERMEDIATES USED THEREIN, AND METHOD OF PREPARING THE INTERMEDIATES
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Paragraph 0332-0336; 0345-0349, (2019/10/22)
The present invention provides a method for manufacturing a (3r,5r)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-((4-hydroxymethylphenylamino)carbonyl)-pyrrol-1-yl)-3,5-dihydroxy-heptanoic acid hemi-calcium salt, an intermediate thereof, and a manufacturing method thereof. According to the present invention, the manufacturing method is performed in a convergent synthesis method of individually synthesizing each main structural part of the (3r,5r)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-((4-hydroxymethylphenylamino)carbonyl)-pyrrol-1-yl)-3,5-dihydroxy-heptanoic acid hemi-calcium salt and coupling the synthesized main structural parts. Accordingly, a flexible material can be easily controlled and manufacturing time can be reduced, thereby increasing productivity of a compound and yield of the final compound.COPYRIGHT KIPO 2019