135635-46-0

Basic information

• Product Name: (E)-17-ethyl-1,14-dihydroxy-12[(E)-2-(4-hydroxy-3-Methoxycyclohexyl)-1-Methylvinyl]-23,25-diMethoxy-13,19,21,27-tetraMethyl-11,28-dioxa-4-azatricyclo[22.3.1.0(super4,9)]octacos-18-ene-2,3,10,16-tetrone
• Synonyms: (E)-8-Ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(E)-2-(4-hydroxy-3-methoxycyclohexyl)-1-methylvinyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21-(4H,23H)-tetrone;Tacrolimus Related Compound A (15 mg) (See USP Certificate for full Chemical Name);(E)-17-ethyl-1,14-dihydroxy-12[(E)-2-(4-hydroxy-3-Methoxycyclohexyl)-1-Methylvinyl]-23,25-diMethoxy-13,19,21,27-tetraMethyl-11,28-dioxa-4-azatricyclo[22.3.1.0(super4,9)]octacos-18-ene-2,3,10,16-tetrone;TacroliMus Related CoMpound A;8-Ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone;(E)-8-Ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(E)-2-(4-hydroxy-3-methoxycyclohexyl)-1-methylvinyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-ep
• CAS NO: 135635-46-0
• Molecular Formula: C₄₃H₆₉NO₁₂
• Molecular Weight: 792.00746
• Mol File: 135635-46-0.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (E)-17-ethyl-1,14-dihydroxy-12[(E)-2-(4-hydroxy-3-Methoxycyclohexyl)-1-Methylvinyl]-23,25-diMethoxy-13,19,21,27-tetraMethyl-11,28-dioxa-4-azatricyclo[22.3.1.0(super4,9)]octacos-18-ene-2,3,10,16-tetrone(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-17-ethyl-1,14-dihydroxy-12[(E)-2-(4-hydroxy-3-Methoxycyclohexyl)-1-Methylvinyl]-23,25-diMethoxy-13,19,21,27-tetraMethyl-11,28-dioxa-4-azatricyclo[22.3.1.0(super4,9)]octacos-18-ene-2,3,10,16-tetrone(135635-46-0)
• EPA Substance Registry System: (E)-17-ethyl-1,14-dihydroxy-12[(E)-2-(4-hydroxy-3-Methoxycyclohexyl)-1-Methylvinyl]-23,25-diMethoxy-13,19,21,27-tetraMethyl-11,28-dioxa-4-azatricyclo[22.3.1.0(super4,9)]octacos-18-ene-2,3,10,16-tetrone(135635-46-0)

Safety Data

• Hazardous Substances Data: 135635-46-0(Hazardous Substances Data)

Usage

General Description

The chemical compound "(E)-17-ethyl-1,14-dihydroxy-12[(E)-2-(4-hydroxy-3-Methoxycyclohexyl)-1-Methylvinyl]-23,25-diMethoxy-13,19,21,27-tetraMethyl-11,28-dioxa-4-azatricyclo[22.3.1.0(super4,9)]octacos-18-ene-2,3,10,16-tetrone" is a complex organic molecule that contains multiple functional groups, including ethyl, hydroxyl, methoxy, and cyclohexyl groups. The compound also features a 4-azatricyclo[22.3.1.0(super4,9)]octacos-18-ene-2,3,10,16-tetrone core structure. It is a polyketide compound with a highly intricate and unique chemical structure. The molecule's complexity and specific arrangement of functional groups give it potentially diverse and significant biological activity, making it of interest for further study in medicinal chemistry and drug development.

Upstream product

• 137071-45-5 24,33-bis-OTBDMS-ascomycin 
• 671222-63-2 11-epi-ascomycin 
• 273752-75-3 2(R),10(S),11(S)-cyclo-ascomycin 
• 668990-42-9 C₆₁H₁₁₃NO₁₂Si₃ 
• 668990-40-7 C₆₁H₁₁₁NO₁₂Si₃ 
• 668990-41-8 C₆₁H₁₁₃NO₁₃Si₃ 

Downstream Products

• 133941-74-9 33-O-(tert-butyldimethylsilyl)-ascomycin 
• 133876-12-7 C₄₃H₆₉NO₁₂ 
• 143839-74-1 L 685818 
• 134226-79-2 33-(tert-butyldimethylsilyl)-24-deoxy-ascomycin 
• 148146-94-5 C₅₂H₇₇NO₁₄ 
• 137071-45-5 24,33-bis-OTBDMS-ascomycin 
• 233600-08-3 ascomycin hydrazone 
• 144939-83-3 9-Deoxo-FR 900520 
• 261759-01-7 17-but-1-enyl-1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-21,23-dimethoxy-13,17,19,25-tetramethyl-11,26-dioxa-4-aza-tricyclo[20.3.1.0^4,9]hexacosane-2,3,10,16-tetraone 
• 261759-00-6 4-β-methoxy-9-dihydroascomycin 

Relevant articles and documents

METHOD OF PURIFYING MACROLIDES

A method for purifying macrolide is provided in which a loading charge of macrolide is placed in juxtaposition with a bed of wet sorption resin, the loading charge and bed are eluted at a temperature greater than 30°C with an eluent of an organic solvent selected from the group consisting of THF, acetonitrile, n-propyl alcohol, iso-propyl alcohol, ethyl alcohol, and acetone, the heart cut of the eluent is collected, and purified macrolide is collected.

A PROCESS FOR THE RECOVERY OF SUBSTANTIALLY PURE TRICYCLIC MACROLIDE

Process for the recovery of a macrolide in substantially pure form comprising: a) treating the macrolide with water immiscible solvent followed by concentration, b) mixing with water, water miscible solvent or mixture thereof, c) performing hydrophobic interaction chromatography and collecting the fractions, d)extracting the fraction containing macrolide with water immiscible solvent followed by concentration, e) adding water miscible solvent to effect separation of impurities from the macrolide compound, f) performing silica gel chromatography and collecting the fractions, g) isolating the macrolide compound in substantially pure form. The macrolide is preferably rapamycin, tacrolimus or immunomycin.

Selective transformation of ascomycin into 11-epi-ascomycin

Within the binding domain, ascomycin features the unusual pattern of a masked tricarbonyl moiety, which potentially allows for high structural diversity via simple isomerisation events. A cascade of diastereoselective rearrangement reactions at the binding domain, allowing the conversion of ascomycin into 11-epi-ascomycin is herein reported.