135645-64-6Relevant articles and documents
Highly Regioselective Bromination Reactions of Polymethylpyrimidines
Strekowski, Lucjan,Wydra, Roman L.,Janda, Lubomir,Harden, Donald B.
, p. 5610 - 5614 (2007/10/02)
4,5-Dimethyl- and 4,5,6-trimethyl-substituted pyrimidines are brominated at C5-Me with NBS in CCl4 and at C4(6)-Me with bromine in acetic acid to give the corresponding bromomethyl derivatives in a high yield.The remaining methyl group(s) can also be brominated with high regioselectivity.The 2-methylthio substituent is not oxidized under these conditions.