1357001-13-8Relevant articles and documents
Novel Raman-tagged sphingomyelin that closely mimics original raft-forming behavior
Cui, Jin,Matsuoka, Shigeru,Kinoshita, Masanao,Matsumori, Nobuaki,Sato, Fuminori,Murata, Michio,Ando, Jun,Yamakoshi, Hiroyuki,Dodo, Kosuke,Sodeoka, Mikiko
, p. 2989 - 2994 (2015)
Abstract Three Raman probes of sphingomyelin (SM) were synthesized and evaluated for their applicability to imaging experiments. One probe containing a hydroxymethyl-1,3-butadiyne moiety in the polar head group showed strong scattering. The solid-state 2H NMR spectra of this probe in oriented bilayer membrane revealed excellent compatibility with natural SM in phase behavior since the probe undergoes phase separation to form raft-like liquid ordered (Lo) domains in the raft-mimicking mixed bilayers.