135705-63-4

Basic information

• Product Name: 7-oxo-3-(1'-carbethoxypropan-2'-one)-cholest-5-ene
• Synonyms: 7-oxo-3-(1'-carbethoxypropan-2'-one)-cholest-5-ene
• CAS NO: 135705-63-4
• Molecular Weight: 512.773
• Mol File: 135705-63-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7-oxo-3-(1'-carbethoxypropan-2'-one)-cholest-5-ene(CAS DataBase Reference)
• NIST Chemistry Reference: 7-oxo-3-(1'-carbethoxypropan-2'-one)-cholest-5-ene(135705-63-4)
• EPA Substance Registry System: 7-oxo-3-(1'-carbethoxypropan-2'-one)-cholest-5-ene(135705-63-4)

Safety Data

• Hazardous Substances Data: 135705-63-4(Hazardous Substances Data)

Upstream product

• 55105-71-0 (8S,9S,10R,13R,14S,17R)-3-Chloro-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-1,2,3,4,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-7-one 
• 123-54-6 acetylacetone 
• 809-51-8 3β-acetoxycholest-5-en-7-one 

Relevant articles and documents

Reaction of ethyl acetoacetate with steroidal enones: Synthesis of steroidal pyrans and related compounds

Reaction of ethyl acetoacetate with several steroidal enones in the cholestane series, in the presence of fused zinc chloride in acetic acid-acetic anhydride, has been described.Cholesta-3,5-dien-7-one (I) furnishes 7-oxo-3-(1'carbethoxypropan-2'-one)-cholest-5-ene (VII) and 7-acetoxy-3'-carbethoxy-2'-methylcholest-6-eno-3,4-dihydropyran (VIII).Under similar reaction conditions II and III provide the dienone (I), VII and VIII.Cholest-5-en-7-one (IV) affords 7-acetoxy-5ξ-(1'-propan-2'-one)-cholest 7-ene (IX) and 7-acetoxy-5ξ-(1'-carbethoxypropan-2'-one)-cholest-6-ene (X).Cholest-4-en-3-one (V) likewise gives 5α-acetoxycholestan-3-one (XI) and the pyrans, 3-acetoxy-3'-carbethoxy-2'-methylcholestanol-3',4'-dihydropyran (XII) and its 3-hydroxy analogue (XIII).Out of curosity the reaction of 3α,5α-cyclo-cholestan-6-one with ethyl acetoacetate has also been carried out.This provides 3β-acetoxy-5α-cholestan-6-one (XIV), cholest-4-en-6-one (XV) and the latter's artefact, 3'-carbethoxy-2'-methyl-4,6-cholestadieno2',3'-dihydropyran (XVI).The structures of the compounds have been established by elemental analyses, spectral data and in some cases by comparison with the known samples.