1357171-41-5

Basic information

• Product Name: C₂₁H₁₆ClN₃O₃
• CAS NO: 1357171-41-5
• Molecular Weight: 393.829
• Mol File: 1357171-41-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₁₆ClN₃O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₁₆ClN₃O₃(1357171-41-5)
• EPA Substance Registry System: C₂₁H₁₆ClN₃O₃(1357171-41-5)

Safety Data

• Hazardous Substances Data: 1357171-41-5(Hazardous Substances Data)

Upstream product

• 1186040-05-0 methyl 5-chlorobenzo[c][2,6]naphthyridine-7-carboxylate 
• 113206-03-4 2-chloro-3-methoxyphenylamine 
• 1186039-90-6 methyl 5-oxo-5,6-dihydrobenzo[c][2,6]naphthyridine-7-carboxylate 

Downstream Products

• 1357171-61-9 C₂₀H₁₄ClN₃O₃ 
• 1350625-11-4 C₂₁H₁₇ClN₄O₂ 

Relevant articles and documents

7-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: A novel class of Pim kinase inhibitors with potent cell antiproliferative activity

A novel class of pan-Pim kinase inhibitors was designed by modifying the CK2 inhibitor CX-4945. Introduction of a triazole or secondary amide functionality on the C-7 position and 2′-halogenoanilines on C-5 resulted in potent inhibitors of the Pim-1 and Pim-2 isoforms, with many analogs active at single digit nanomolar concentrations. The molecules inhibited the phosphorylation at Serine 112 of the apoptosis effector BAD, and had potent antiproliferative effects on the AML cell line MV-4-11 (IC50 30 nM). This work delivers an excellent lead-optimization platform for Pim targeting anticancer therapies.