13572-24-2Relevant articles and documents
Synthesis and antimicrobial evaluation of novel pyrazolones and pyrazolone nucleosides
Hassan, Abdalla E. A.,Moustafa, Ahmed H.,Tolbah, Mervat M.,Zohdy, Hussein F.,Haikal, Abdelfattah Z.
, p. 783 - 800 (2013/01/16)
The synthesis of a novel series of 4-Arylhydrazono-5-methyl-1,2- dihydropyrazol-3-ones 4a-h, and their N 2-Alkyl and acyclo, glucopyranosyl, and ribofuranosyl derivatives is described. K2CO 3 catalyzed alkylation of 4a-h with allyl bromide, propargyl bromide, 4-bromobutyl acetate, 2-Acetoxyethoxymethyl bromide, and 2,3,4,6-tetra-O- Acetyl-D-glucopyranosyl bromide proceeded selectively at the N 2-position of the pyrazolinone ring. Glycosylation of 4a with 1,2,3,5-tetra-O-Acetyl-D-ribofuranose under Vorbruggen glycosylation conditions gave the corresponding N 2-4-Arylhydrazonopyrazolone ribofuranoside 9a in good yield. Conventional deprotection of the acetyl protected nucleosides furnished the corresponding 4-Arylhydrazonopyrazolone nucleosides in good yields. Selected numbers of the newly synthesized compounds were screened for antimicrobial activity. Compounds 4b, 12a, and 14d showed moderate activities against Aspergillus flavus, Penicillium sp., and Escherichia coli.
Synthesis of some new phenylthiocarbamoyl 2-pyrazolin-5-ones of pharmaceutical interest
Metwally,Abdel-Latif,Amer
, p. 213 - 216 (2007/10/03)
Thiocarbamoylation reaction of 3-methyl-2-pyrazolin-5-one (1a) with two equivalents of PhNCS, resulted in the formation of 1,4-di(α-phenylthiocarbamoyl)-3-methylpyrazolone 3, which underwent cleavage of the thiocarbamoyl group at position 4 when coupled w
