135722-55-3Relevant articles and documents
Synthesis of novel and conformationally constrained bridged amino acids as compact modules for drug discovery
Wu, Guolong,Kou, Buyu,Tang, Guozhi,Zhu, Wei,Shen, Hong C.,Liu, Haixia,Hu, Taishan
, p. 599 - 602 (2016)
As novel scaffolds with rigid inherent three-dimensional conformation, the bridged amino acid building blocks containing both morpholine and pyrrolidine motifs, 2-oxa-5-azabicyclo[2.2.1]heptane-4-carboxylic acid 1 and 3-oxa-8-azabicyclo[3.2.1]octane-5-carboxylic acid 2, were first synthesized as compact modules for future applications in the optimization of physicochemical and pharmacokinetic properties of drug candidates in drug discovery.
Nonenzymatic enantioselective monoacetylation of prochiral 2-protectedamino-2-alkyl-1,3-propanediols utilizing a chiral sulfonamide-Zn complex catalyst
Honjo, Takashi,Nakao, Michiyasu,Sano, Shigeki,Shiro, Motoo,Yamaguchi, Kentaro,Sei, Yoshihisa,Nagao, Yoshimitsu
, p. 509 - 512 (2007/10/03)
Treatment of a chiral sulfonamide with Et2Zn gave quantitatively its Zn complex and then the structure was determined by X-ray crystallographic analysis. Reaction of prochiral W-Boc-2-amino-2-alkyl-1,3-propanediols with Ac2O in the presence of 5 mol% of chiral sulfonamide - Zn complex catalyst afforded the corresponding chiral monoacetyl products in 70-92% yields with 70-88% ee values. The proposed mechanism for the catalytic monoacetylation of a prochiral 1,3-propanediol was presented on the basis of CSI-MS analysis.
Synthesis of Modified Partial Structures of the Bacterial Cell Wall. 1. Lipopeptides Containing Nonproteinogenic Amino Acids
Schneider, Helmut,Sigmund, Gerhard,Schricker, Bettina,Thirring, Klaus,Berner, Heinz
, p. 683 - 689 (2007/10/02)
Two stereoisomeric lipopeptides 1 and 2 which can be regarded as modified peptidoglycans have been synthesized by using three different reaction sequences.The ene reaction of the α-allylated dipeptide 12 with butyl glyoxylate was used as a key step.The re
