1357261-63-2

Basic information

• Product Name: (1S,2R,3S,4R)-2-(4-fluorophenyl)-3,4-epoxycyclopentan-1-ol
• Synonyms: (1S,2R,3S,4R)-2-(4-fluorophenyl)-3,4-epoxycyclopentan-1-ol
• CAS NO: 1357261-63-2
• Molecular Weight: 194.206
• Mol File: 1357261-63-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1S,2R,3S,4R)-2-(4-fluorophenyl)-3,4-epoxycyclopentan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2R,3S,4R)-2-(4-fluorophenyl)-3,4-epoxycyclopentan-1-ol(1357261-63-2)
• EPA Substance Registry System: (1S,2R,3S,4R)-2-(4-fluorophenyl)-3,4-epoxycyclopentan-1-ol(1357261-63-2)

Safety Data

• Hazardous Substances Data: 1357261-63-2(Hazardous Substances Data)

Upstream product

• 115074-49-2 (1R,4S)-4-[(tert-butyldimethylsilyl)oxy]-2-cyclopentene-1-yl acetate 
• 120520-91-4 (1R,4S)-4-(tert-butyldimethylsilyloxy)cyclopent-2-enol 
• 60410-16-4 (1R,4S)-4-hydroxy-2-cyclopentene-1-yl acetate 
• 352-34-1 4-fluoro-1-iodobenzene 
• 1357261-59-6 (1R,4S)-4-hydroxycyclopent-2-enyl 2-methoxyacetate 
• 1357261-90-5 C₁₁H₁₆O₆ 

Downstream Products

• 1357261-76-7 (1R,2S,3S)-3-(tert-butyldimethylsilyloxy)-2-(4-fluorophenyl)cyclopentan-1-ol 
• 1357261-78-9 (1S,2S,3S)-3-(tert-butyldimethylsilyloxy)-2-(4-fluorophenyl)cyclopentyl 3,5-dinitrobenzoate 
• 1357261-80-3 C₁₇H₂₇FO₂Si 
• 1357261-82-5 C₂₅H₃₀FNO₃Si 
• 1357261-58-5 (1R,2S,3S)-3-(tert-butyldimethylsilyloxy)-2-(4-fluorophenyl)cyclopentanamine 
• 1357261-87-0 C₂₅H₃₀FNO₃Si 
• 1357261-88-1 (1S,2S,3S)-3-(tert-butyldimethylsilyloxy)-2-(4-fluorophenyl)cyclopentanamine 
• 1357261-89-2 (1S,2S,3S,4R)-1-(tert-butyldimethylsilyloxy)-2-(4-fluorophenyl)-3,4-epoxycyclopentane 

Relevant articles and documents

Synthesis of an advanced intermediate toward the hNK-1 antagonist with the cyclopentane core

Allylic substitution of monomethoxyacetate of 4-cyclopentene-1,3-diol (91% ee) with 4-FC6H4ZnBr (4 equiv) and CuCl (30 mol%) gave anti-SN2 product, which upon epoxidation with MCPBA afforded -epoxide stereoselectively. The epoxide was reduced with LiEt3BH, and the resulting alcohol was converted into the targeted amine by using Mitsunobu reactions twice with 3,5-(O2N)2C6H 3CO2H and then with phthalimide. Georg Thieme Verlag Stuttgart · New York.