1357261-73-4Relevant articles and documents
Synthesis of an advanced intermediate toward the hNK-1 antagonist with the cyclopentane core
Nakata, Kenya,Kiyotsuka, Yohei,Kitazume, Tomoya,Kobayashi, Yuichi
, p. 2872 - 2874 (2012/01/06)
Allylic substitution of monomethoxyacetate of 4-cyclopentene-1,3-diol (91% ee) with 4-FC6H4ZnBr (4 equiv) and CuCl (30 mol%) gave anti-SN2 product, which upon epoxidation with MCPBA afforded -epoxide stereoselectively. The epoxide was reduced with LiEt3BH, and the resulting alcohol was converted into the targeted amine by using Mitsunobu reactions twice with 3,5-(O2N)2C6H 3CO2H and then with phthalimide. Georg Thieme Verlag Stuttgart · New York.