1357287-75-2

Basic information

• Product Name: (1E,4E)-1,5-bis(3-bromopyridin-2-yl)penta-1,4-dien-3-one
• Synonyms: (1E,4E)-1,5-bis(3-bromopyridin-2-yl)penta-1,4-dien-3-one
• CAS NO: 1357287-75-2
• Molecular Weight: 394.065
• Mol File: 1357287-75-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1E,4E)-1,5-bis(3-bromopyridin-2-yl)penta-1,4-dien-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: (1E,4E)-1,5-bis(3-bromopyridin-2-yl)penta-1,4-dien-3-one(1357287-75-2)
• EPA Substance Registry System: (1E,4E)-1,5-bis(3-bromopyridin-2-yl)penta-1,4-dien-3-one(1357287-75-2)

Safety Data

• Hazardous Substances Data: 1357287-75-2(Hazardous Substances Data)

Upstream product

• 38749-79-0 3-bromo-2-picoline 
• 67-64-1 acetone 
• 405174-97-2 3-bromopicolinaldehyde 
• 14559-87-6 isopropenylboronic acid 

Relevant articles and documents

Synthesis of the pyridinyl analogues of dibenzylideneacetone (pyr-dba) via an improved Claisen-Schmidt condensation, displaying diverse biological activities as curcumin analogues

An efficient and easy procedure to synthesize the pyridinyl analogues of dibenzylideneacetone (pyr-dba) was developed by the condensation of substituted nicotinaldehyde and acetone in the presence of K2CO3 in toluene-EtOH-H2O solvent system. Structurally diverse pyr-dba, including quinolinyl dba, can be prepared conveniently in moderate to excellent yields under mild conditions with this method. The resulting pyr-dba functioned as the enone analogs of curcumin and efficiently inhibited the activation of NF-κB and the growth of colorectal carcinoma HCT116 p53+/+ cells as well as the HIV-1 IN-LEDGF/p75 interaction. The Royal Society of Chemistry 2012.