1357302-64-7

Basic information

• Product Name: OG-L002
• Synonyms: OG-L002;[1,1'-Biphenyl]-3-ol, 4'-[(1R,2S)-2-aminocyclopropyl]-4'-((1R,2S)-2-Aminocyclopropyl)biphenyl-3-o;OG-L002 [1,1'-Biphenyl]-3-ol, 4'-[(1R,2S)-2-aminocyclopropyl]-;OG-L002 4'-((1S,2R)-2-aminocyclopropyl)-[1,1'-biphenyl]-3-ol 3-[4-[(1R,2S)-2-aminocyclopropyl]phenyl]phenol;4'-((1R,2S)-2-Aminocyclopropyl)biphenyl-3-ol;4'-((1R,2S)-2-Aminocyclopropyl)-[1,1'-biphenyl]-3-ol
• CAS NO: 1357302-64-7
• Molecular Formula: C15H15NO
• Molecular Weight: 225.29
• Product Categories: Inhibitors
• Mol File: 1357302-64-7.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 416.7±45.0 °C(Predicted)
• Appearance: /
• Density: 1.193±0.06 g/cm3(Predicted)
• Solubility: insoluble in H2O; ≥22.5 mg/mL in DMSO; ≥6.82 mg/mL in EtOH
• PKA: 9.78±0.10(Predicted)
• CAS DataBase Reference: OG-L002(CAS DataBase Reference)
• NIST Chemistry Reference: OG-L002(1357302-64-7)
• EPA Substance Registry System: OG-L002(1357302-64-7)

Safety Data

• Hazardous Substances Data: 1357302-64-7(Hazardous Substances Data)

Usage

Description

OG-L002 is a potent and selective inhibitor of Lysine-specific demethylase 1 (LSD1), also known as KDM1A. This protein lysine demethylase is responsible for the demethylation of histone H3 lysine 4 (H3K4) and H3K9, leading to transcriptional repression. OG-L002 effectively inhibits LSD1 with an IC50 of 0.02 μM and has a lower impact on monoamine oxidases A (MAO-A) and MAO-B (IC50s of 1.38 and 0.72 μM, respectively). It is particularly effective in blocking the expression of immediate early (IE) genes of herpes simplex virus (HSV) in HeLa cells without affecting cellular control genes. Additionally, OG-L002 reduces the expression of human cytomegalovirus IE genes and adenovirus E1A gene in mammalian cells. It has demonstrated efficacy in vivo, repressing HSV primary infection in mice and blocking HSV reactivation from latency in a mouse ganglion explant model.

Uses

Used in Antiviral Applications:
OG-L002 is used as an antiviral agent for blocking the lytic replication and reactivation of herpes simplex virus (HSV) from latency. It achieves this by inhibiting the LSD1 enzyme, which is involved in the regulation of viral genes necessary for infection.
Used in Pharmaceutical Industry:
OG-L002 is used as a potent inhibitor of LSD1 for the development of new therapeutic strategies against various viral infections. Its ability to block the expression of immediate early genes in different viruses makes it a promising candidate for the treatment of infections caused by herpes simplex virus, human cytomegalovirus, and adenovirus.
Used in Research and Development:
OG-L002 is used as a research tool for studying the role of LSD1 in viral infections and the regulation of gene expression. Its selectivity and potency make it a valuable compound for investigating the underlying mechanisms of viral latency and reactivation, as well as for identifying potential targets for antiviral drug development.