135731-20-3

Basic information

• Product Name: Carbamic acid, [1-[[(methylsulfonyl)oxy]methyl]-2-phenylethyl]-, phenylmethyl ester, (S)-
• CAS NO: 135731-20-3
• Molecular Formula: C18H21NO5S
• Molecular Weight: 363.434
• Mol File: 135731-20-3.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [1-[[(methylsulfonyl)oxy]methyl]-2-phenylethyl]-, phenylmethyl ester, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [1-[[(methylsulfonyl)oxy]methyl]-2-phenylethyl]-, phenylmethyl ester, (S)-(135731-20-3)
• EPA Substance Registry System: Carbamic acid, [1-[[(methylsulfonyl)oxy]methyl]-2-phenylethyl]-, phenylmethyl ester, (S)-(135731-20-3)

Safety Data

• Hazardous Substances Data: 135731-20-3(Hazardous Substances Data)

Usage

Description

Carbamic acid, [1-[[(methylsulfonyl)oxy]methyl]-2-phenylethyl]-, phenylmethyl ester, (S)is a carbamic acid ester and the (S)-enantiomer of montelukast, a medication used to treat asthma and allergic rhinitis. It works by blocking leukotrienes, inflammatory substances in the body that can cause asthma and allergic rhinitis symptoms. It is a potent and selective leukotriene receptor antagonist and is available in tablet, chewable tablet, and oral granule forms for administration.

Uses

Used in Pharmaceutical Industry:
Carbamic acid, [1-[[(methylsulfonyl)oxy]methyl]-2-phenylethyl]-, phenylmethyl ester, (S)is used as a medication for treating asthma and allergic rhinitis. It is effective in blocking leukotrienes, reducing inflammation and alleviating symptoms associated with these conditions.
Used in Healthcare:
Carbamic acid, [1-[[(methylsulfonyl)oxy]methyl]-2-phenylethyl]-, phenylmethyl ester, (S)is used as a prescription medication by healthcare professionals to manage and alleviate symptoms associated with asthma and allergies. It is marketed under the brand name Singulair and is often prescribed to patients who suffer from these conditions.

Upstream product

• 6372-14-1 N-((benzyloxy)carbonyl)-L-phenylalaninol 
• 124-63-0 methanesulfonyl chloride 
• 3182-95-4 L-Phenylalaninol 
• 501-53-1 benzyl chloroformate 
• 41518-17-6 Z-Phe-O-COO-isoBu 
• 1161-13-3 N-Cbz-L-Phe 

Downstream Products

• 856570-20-2 (S)-2-Benzyloxycarbonylamino-3-phenyl-propane-1-sulfonic acid 
• 1300689-96-6 L-Phe-[CH₂SO₂]-FHCl 
• 1169199-29-4 Cbz-Phe-ψ[CH2SO2NH]-β-Ala-ψ[CH2SO2]-F 
• 1169199-24-9 Cbz-Phe-ψ[CH2SO2]-F 
• 172695-21-5 (S)-2-(N-benzyloxyacarbonylamino)-3-phenylpropyl cyanide 
• 126301-32-4 (S)-2-amino-3-phenylpropane-1-sulfonic acid 
• 154484-06-7 (S)-N-(2-benzyloxycarbonylamino-3-phenylpropyl)-L-proline tert-butyl ester 
• 167298-42-2 N²-benzyloxycarbonyl-3-phenyl-1,2-propanediamine 
• 85612-60-8 (2S)-3-phenylpropane-1,2-diamine 

Relevant articles and documents

Novel sulfonamide-based carbamates as selective inhibitors of bche

A series of 14 target benzyl [2-(arylsulfamoyl)-1-substituted-ethyl]carbamates was prepared by multi-step synthesis and characterized. All the final compounds were tested for their abil-ity to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase

Selective inhibition of the immunoproteasome by ligand-induced crosslinking of the active site

The concept of proteasome inhibition ranks among the latest achievements in the treatment of blood cancer and represents a promising strategy for modulating autoimmune diseases. In this study, we describe peptidic sulfonyl fluoride inhibitors that selecti

Synthesis of novel N-protected β3-amino nitriles: study of their hydrolysis involving a nitrilase-catalyzed step

Several commercially available nitrilases were investigated with regard to their potential to hydrolyze N-protected β3-amino nitriles into their corresponding N-protected β3-amino acids. The biotransformations were obtained in different proportions depending on the nitrilase involved. The best hydrolysis results were achieved for the N-Cbz-β3-amino nitrile from l-alanine using the NIT-107, in a phosphate buffer at 0.05 M. However, no biotransformation into the corresponding acids was observed for the N-sulfonylamide β3-amino nitriles. Two simple and efficient procedures to prepare the β3-amino nitriles from their analogous α-amino acids are described. Thirty four new substances were synthesized and characterized over the course of this work.