135746-09-7

Basic information

• Product Name: 2'-hydroxy-6'-methoxychalcone epoxide
• CAS NO: 135746-09-7
• Molecular Weight: 270.285
• Mol File: 135746-09-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2'-hydroxy-6'-methoxychalcone epoxide(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-hydroxy-6'-methoxychalcone epoxide(135746-09-7)
• EPA Substance Registry System: 2'-hydroxy-6'-methoxychalcone epoxide(135746-09-7)

Safety Data

• Hazardous Substances Data: 135746-09-7(Hazardous Substances Data)

Upstream product

• 136257-63-1 2'-methoxy-6'-tetrahydropyranyloxychalcone 
• 136257-62-0 2'-methoxy-6'-tetrahydropyranyloxyacetophenone 
• 63854-17-1 2-hydroxy-6-[(tetrahydro-2H-pyran-2-yl)oxy]acetophenone 
• 699-83-2 2,6-dihydroxylacetophenone 
• 136257-64-2 2'-methoxy-6'-tetrahydropyranyloxychalcone epoxide 

Downstream Products

• 60188-58-1 3-hydroxy-5-methoxyflavanone 
• 135746-16-6 erythro-4-methoxyaurone hydrate 
• 7169-35-9 4-methoxybenzofuran-3(2H)-one 
• 57060-62-5 (Z)-2-benzylidene-4-methoxybenzofuran-3(2H)-one 

Relevant articles and documents

Synthesis of 2'-hydroxychalcone epoxides

Various preparations of some 2'-tetrahydropyran-2-yloxychalcone epoxides and removal of their tetrahydropyranyl (THP) protective groups in slightly aqueous acidic dioxane are described. So synthesised were 2'-hydroxy-6'-isopropoxy- and 2'-hydroxy-6'-methoxychalcone epoxide, as well as the 2-CF3, 4-Cl and 4-NO2 analogues of the latter. 2',4'-dihydroxy-6'-methoxychalcone epoxide was similarly prepared. In some other 6'-methoxy cases protective group removal was accompanied by epoxide solvolysis and the corresponding α,β-dihydroxydihydrochalcone was the only isolable product [2-OMe, 4-OMe, 3,4,5-(OMe)3 cases] or a byproduct [4-Me case]. Similarly prepared by THP removal were 2'-hydroxy-4'-methoxychalcone epoxide and 2',4'-dihydroxychalcone epoxide, whereas an attempt to convert 2',6'-ditetrahydropyranyloxychalcone epoxide into 2',6'-dihydroxychalcone epoxide gave the product of cyclisation of the latter, 3,5-dihydroxyflavanone.