1357581-63-5Relevant articles and documents
CuI-mediated sequential iodination/cycloetherification of o-arylphenols: Synthesis of 2- or 4-iododibenzofurans and mechanistic studies
Zhao, Jiaji,Liu, Lanying,He, Yimiao,Li, Jing,Zhu, Qiang,Zhang, Qi,Li, Juan
supporting information, p. 5362 - 5365,4 (2012/12/12)
An efficient synthesis of 2- or 4-iododibenzofurans through CuI-mediated sequential iodination/cycloetherification of two aromatic C-H bonds in o-arylphenols has been developed. Both the preexisting electron-withdrawing groups (NO2, CN, and CHO) and the newly introduced iodide are readily modified for a focused dibenzofuran library synthesis. Mechanistic studies and DFT calculations suggest that a Cu(III)-mediated rate-limiting C-H activation step is involved in cycloetherification.
