135777-62-7

Basic information

• Product Name: (4R)-1-benzyl-4-(t-butyloxycarbonyl)-3,3-difluoroazetidin-2-one
• CAS NO: 135777-62-7
• Molecular Weight: 297.302
• Mol File: 135777-62-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (4R)-1-benzyl-4-(t-butyloxycarbonyl)-3,3-difluoroazetidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (4R)-1-benzyl-4-(t-butyloxycarbonyl)-3,3-difluoroazetidin-2-one(135777-62-7)
• EPA Substance Registry System: (4R)-1-benzyl-4-(t-butyloxycarbonyl)-3,3-difluoroazetidin-2-one(135777-62-7)

Safety Data

• Hazardous Substances Data: 135777-62-7(Hazardous Substances Data)

Upstream product

• 135777-61-6 (4R)-1-benzyl-3,3-difluoro-4-<(1'R)-1',2'-dihydroxyethyl>azetidin-2-one 
• 100-46-9 benzylamine 
• 147633-27-0 ethyl (3R,4R)-3-benzylamino-2,2-difluoro-4,5-O-isopropylidenepentanoate 
• 120316-01-0 (R)-1-Benzyl-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3,3-difluoro-azetidin-2-one 
• 135777-60-5 (4R)-1-benzyl-3,3-difluoro-4-<(4'R)-2',2'-dimethyl-1',3'-dioxolan>-azetidin-2-one 
• 135821-68-0 (S)-N-benzyl-2,3-O-isopropylidene-glyceraldimine 
• 100777-91-1 (2S)-2,3-O-isopropylideneglyceraldehyde N-benzylimine 
• 98946-18-0 tert-Butyl 2,2,2-trichloroacetimidate 

Downstream Products

• 147633-28-1 t-butyl (2R)-2-benzylamino-3,3-difluoro-4-hydroxybutanoate 
• 147730-78-7 (3R)-3-benzylamino-2,2-difluorobutane-1,4-diol 

Relevant articles and documents

Isopenicilin N synthase: A new mode of reactivity

Incubation of L-δ-(α-aminoadipoyl)-L-(3,3-difluorohomocysteinyl)-D-valine [an analogue of the natural substrate: L-δ-(α-aminoadipoyl)-L-(cysteinyl)-D-varine] with isopenicillin N synthase (IPNS) resulted in the production of a thiocarboxylic acid, i.e. both equivalents of the dioxygen cosubstrate were utilised to oxidise a single carbon of the cysteinyl analogue. This result and others are rationalised in terms of mechanistic proposals for the first ring closure by IPNS. The synthesis of L-difluorohomocysteine and related structures, via 3,3-difluoro-β-lactams, is described.