1357931-55-5 Usage
Description
Sildenafil EP IMpurity D, also known as Demethylpiperazinyl Sildenafil Sulfonic Acid, is an impurity found in Sildenafil citrate (S435000). It is a chemical compound that is typically present in small amounts within the pharmaceutical product and is subject to regulatory guidelines for its acceptable levels.
Uses
Used in Pharmaceutical Industry:
Sildenafil EP IMpurity D is used as a reference material for the quality control and assessment of Sildenafil citrate products. It helps ensure the purity, safety, and efficacy of the active pharmaceutical ingredient (API) by providing a benchmark for impurity identification and quantification during the manufacturing process.
Additionally, understanding the properties and effects of Sildenafil EP IMpurity D can contribute to the development of improved synthesis methods, purification techniques, and quality control measures for Sildenafil citrate, ultimately enhancing the overall quality and safety of the final pharmaceutical product.
Check Digit Verification of cas no
The CAS Registry Mumber 1357931-55-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,5,7,9,3 and 1 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1357931-55:
(9*1)+(8*3)+(7*5)+(6*7)+(5*9)+(4*3)+(3*1)+(2*5)+(1*5)=185
185 % 10 = 5
So 1357931-55-5 is a valid CAS Registry Number.
1357931-55-5Relevant articles and documents
Sulphonated graphene oxide catalyzed continuous flow synthesis of pyrazolo pyrimidinones, sildenafil and other PDE-5 inhibitors
Sthalam, Vinay Kumar,Mahajan, Bhushan,Karra, Purushotham Reddy,Singh, Ajay K.,Pabbaraja, Srihari
, p. 326 - 330 (2022/01/19)
Sulphonated graphene oxide was used for cascade condensation and cyclization reactions towards accessing substituted pyrazolo pyrimidinones. Further, sulphonation and amination reactions were integrated through continuous flow chemistry to access PDE-5 inhibitors. Herein, we report a simple continuous synthetic platform that reduce tedious manual operations and accelerate the synthesis of several potent inhibitors of phosphodiesterase type-5. The developed platform enabled us to perform one-flow multi-step, multi-operational process to synthesize the PDE-5 inhibitors such as sildenafil and its analogues in 32.3 min of the reaction time, with minimal human intervention and single solvent.
A method for synthesis of impurity D Xidinafei (by machine translation)
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Paragraph 0059; 0060; 0061; 0062-0085, (2019/08/28)
The invention relates to a method for synthesis of impurity D Xidinafei, sulfuryl Xidinafei body chlorine to as raw material in the middle, the middle of the stated Xidinafei sulfurylbody chlorine in adding water and organic solvent, heating to reflux for