135832-74-5

Basic information

• Product Name: <5(S)-<(tert-butoxycarbonyl)amino>-4(S)-(tertbutyldimethylsiloxy)-6-phenyl-2(R)-(phenylmethyl)hexanoyl>valine amide
• CAS NO: 135832-74-5
• Molecular Weight: 625.924
• Mol File: 135832-74-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: <5(S)-<(tert-butoxycarbonyl)amino>-4(S)-(tertbutyldimethylsiloxy)-6-phenyl-2(R)-(phenylmethyl)hexanoyl>valine amide(CAS DataBase Reference)
• NIST Chemistry Reference: <5(S)-<(tert-butoxycarbonyl)amino>-4(S)-(tertbutyldimethylsiloxy)-6-phenyl-2(R)-(phenylmethyl)hexanoyl>valine amide(135832-74-5)
• EPA Substance Registry System: <5(S)-<(tert-butoxycarbonyl)amino>-4(S)-(tertbutyldimethylsiloxy)-6-phenyl-2(R)-(phenylmethyl)hexanoyl>valine amide(135832-74-5)

Safety Data

• Hazardous Substances Data: 135832-74-5(Hazardous Substances Data)

Upstream product

• 3014-80-0 (S)-2-amino-3-methylbutanamide hydrochloride 
• 98818-51-0 N-(1,1-dimethylethoxycarbonyl)-5(S)-amino-4(S)-(t-butyldimethylsilyloxy)-6-phenyl-2(R)-(phenylmethyl)hexanoic acid 

Downstream Products

• 126438-22-0 N-{5(S)-[(tert-butoxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2(R)-(phenylmethyl)hexanoyl}valine amide 

Relevant articles and documents

Design and synthesis of HIV protease inhibitors. Variations of the carboxy terminus of the HIV protease inhibitor L-682,679

A series of tetrapeptide analogues of 1 (L-682,679), in which the carboxy terminus has been shortened and modified, was prepared and their inhibitory activity measured against the HIV protease in a peptide cleavage assay. Selected examples were tested as inhibitors of virus spread in cell culture. Compound 12 was a 10-fold more potent enzyme inhibitor than 1 in vitro and 30-fold more potent in inhibiting the viral spread in cells.