135873-35-7

Basic information

• Product Name: 4-(CHLOROMETHYL)-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOLE
• Synonyms: 4-(CHLOROMETHYL)-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOLE;4-(CHLOROMETHYL)-2-[4-(TRIFLUOROMETHYL)PHENYL]-THIAZOLE;Chloromethyltrifluoromethylphenylthiazole;4-(Chloromethyl)-2-[4-(trifluoromethyl)phenyl]thiazole95+%;4-(Chloromethyl)-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole 95+%;4-[4-(Chloromethyl)-1,3-thiazol-2-yl]benzotrifluoride
• CAS NO: 135873-35-7
• Molecular Formula: C₁₁H₇ClF₃NS
• Molecular Weight: 277.69
• Mol File: 135873-35-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: 80 °C
• Boiling Point: 345.7°Cat760mmHg
• Flash Point: 162.9°C
• Appearance: /
• Density: 1.398g/cm³
• Vapor Pressure: 0.000121mmHg at 25°C
• Refractive Index: 1.537
• CAS DataBase Reference: 4-(CHLOROMETHYL)-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(CHLOROMETHYL)-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOLE(135873-35-7)
• EPA Substance Registry System: 4-(CHLOROMETHYL)-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOLE(135873-35-7)

Safety Data

• Hazard Codes: C
• Statements: R34:Causes burns.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36/37/39:Wear suitabl
• Hazardous Substances Data: 135873-35-7(Hazardous Substances Data)

Usage

General Description

4-(Chloromethyl)-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole is a compound with the chemical formula C11H7ClF3NS. It is a thiazole derivative with a chloromethyl group attached to the second position and a trifluoromethylphenyl group attached to the fourth position of the thiazole ring. This chemical compound is commonly used in pharmaceutical and agrochemical research due to its potential biological activities. It has been studied for its antimicrobial, antifungal, and antitumor properties, making it a valuable target for drug development. Additionally, it has been investigated for its potential as a building block for synthesizing other organic compounds with diverse biological activities.

InChI:InChI=1/C11H7ClF3NS/c12-5-9-6-17-10(16-9)7-1-3-8(4-2-7)11(13,14)15/h1-4,6H,5H2

Upstream product

• 72505-21-6 4-trifluoromethylbenzthioamide 
• 534-07-6 1,3-Dichloroacetone 
• 455-18-5 4-CF₃C₆H₄CN 

Downstream Products

• 915124-70-8 2-[2-(4-trifluoromethyl-phenyl)-thiazol-4-ylmethyl]-2-(3,3,3-trifluoropropyl)-malononitrile 
• 690632-10-1 {2-[4-(trifluoromethyl)phenyl]thiazol-4-yl}methylamine hydrochloride 

Relevant articles and documents

Design, synthesis, fungicidal activities and structure–activity relationship studies of (?)-borneol derivatives containing 2-aryl-thiazole scaffold

A series of (-)-borneol derivatives containing 2-aryl-thiazole scaffold were designed, synthesized, and characterized by 1H NMR, 13C NMR, and HRMS. The fungicidal activities of these novel compounds against Fusarium oxysporum, Magnaporthe grisea, Botrytis cinerea, and Penicillium digitatum were evaluated. The results indicated that (1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl(Z)-4-oxo-4-(((2-phenylthiazol-4-yl)methyl)amino)but-2-enoate (6a) displayed potential fungicidal activities with broad spectrum. Especially, 6a exhibited an IC50 value of 48.5 mg/L against P. digitatum, which has higher fungicidal activity than commercial products hymexazol and amicarthiazol. Moreover, (1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl-4-oxo-4-(((2-phenylthiazol-4-yl)methyl)amino)butanoate (5a) possesses an IC50 value of 24.3 mg/L against B. cinerea, comparable to hymexazol and far superior to amicarthiazol. Furthermore, the superficial structure–activity relationship was discussed, which might be helpful for discovering novel fungicides.

HETEROCYCLIC AMIDE DERIVATIVE AND PHARMACEUTICAL PRODUCT CONTAINING SAME

The present invention aims to provide a novel compound having a TRPA1 antagonist activity, and a medicament containing the compound. Moreover, the present invention aims to provide a TRPA1 antagonist and a medicament useful for the prophylaxis or treatmen

NOVEL 2-ARYLTHIAZOLE COMPOUNDS AS PPARALPHA AND PPARGAMA AGONISTS

The present invention relates to compounds of formula (I) wherein Rl to R10, X, Y and n are as defined in the description and claims, and pharmaceutically acceptable salts and esters thereof. The compounds are useful for the treatment of diseases such as diabetes.