135889-00-8 Usage
Description
(6R,7R)-3-[[(Aminocarbonyl)oxy]methyl]-7-[[(2Z)-2-(2-amino-4-thiazolyl)-1-oxo-2-pentenyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid is a complex organic compound with a unique molecular structure. It is characterized by its thiazolyl and pentenyl functional groups, which contribute to its potential biological activities and applications.
Uses
Used in Pharmaceutical Industry:
(6R,7R)-3-[[(Aminocarbonyl)oxy]methyl]-7-[[(2Z)-2-(2-amino-4-thiazolyl)-1-oxo-2-pentenyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid is used as a pharmaceutical compound for its potential therapeutic applications. The presence of thiazolyl and pentenyl groups may provide it with specific biological activities, making it a candidate for the development of new drugs.
Used in Antibacterial Applications:
As a metabolite of Cefcapene Pivoxil, this compound is used as an orally absorbed cephalosporin antibiotic. It is effective against a range of bacterial infections due to its ability to inhibit bacterial cell wall synthesis, leading to cell lysis and death.
Used in Research and Development:
The unique structure of (6R,7R)-3-[[(Aminocarbonyl)oxy]methyl]-7-[[(2Z)-2-(2-amino-4-thiazolyl)-1-oxo-2-pentenyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid also makes it a valuable compound for research and development purposes. It can be used as a starting material or a reference compound in the synthesis of new drugs or the study of biological processes.
Antimicrobial activity
A semisynthetic cephalosporin formulated for oral administration
as the prodrug ester, cefcapene pivoxil. Activity and
uses are similar to those of cefditoren.
Available in Japan.
Check Digit Verification of cas no
The CAS Registry Mumber 135889-00-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,5,8,8 and 9 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 135889-00:
(8*1)+(7*3)+(6*5)+(5*8)+(4*8)+(3*9)+(2*0)+(1*0)=158
158 % 10 = 8
So 135889-00-8 is a valid CAS Registry Number.
InChI:InChI=1/C17H19N5O6S2/c1-2-3-8(9-6-30-16(18)20-9)12(23)21-10-13(24)22-11(15(25)26)7(4-28-17(19)27)5-29-14(10)22/h3,6,10,14H,2,4-5H2,1H3,(H2,18,20)(H2,19,27)(H,21,23)(H,25,26)/b8-3-/t10-,14-/m1/s1
135889-00-8Relevant articles and documents
Synthesis and structure-activity relationships of 7β-[(Z)-2-(2-aminothiazol-4-yl)-3-(substituted)-2- propenoyl-amino]-3-cephems with C-3 substitutions
Ishikura,Kuboto,Minami,Hamashima,Nakashimizu,Motokawa,Kimura,Miwa,Yoshida
, p. 466 - 476 (2007/10/02)
Synthesis and biological activity of a series of 7β-[(Z)-2-(2-aminothiazol-4-yl)-3-(substituted)-2- propenoylamino]-3-cephem-4-carboxylic acids with C-3 substitutions and their pivaloyloxymethyl esters are described. These acid compounds exhibited potent antibacterial activity against both Gram-positive and Gram-negative bacteria. Pivaloyloxymethyl esters of selected compounds in this series were found to be well absorbed from small intestine in mice. Pivaloyloxymethyl 7β-[(Z)-2-(2-aminothiazol-4-yl)-2-pentenoylamino]-3- carbamoyloxymethyl-3-cephem-4-carboxyiate hydrochloride hydrate (S-1108) was finally selected as the candidate for clinical evaluation.