135938-63-5

Basic information

• Product Name: 2-({[tert-butyl(dimethyl)silyl]oxy}methyl)piperidine
• Synonyms: 2-({[tert-butyl(dimethyl)silyl]oxy}methyl)piperidine
• CAS NO: 135938-63-5
• Molecular Weight: 229.438
• Mol File: 135938-63-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-({[tert-butyl(dimethyl)silyl]oxy}methyl)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-({[tert-butyl(dimethyl)silyl]oxy}methyl)piperidine(135938-63-5)
• EPA Substance Registry System: 2-({[tert-butyl(dimethyl)silyl]oxy}methyl)piperidine(135938-63-5)

Safety Data

• Hazardous Substances Data: 135938-63-5(Hazardous Substances Data)

Usage

Molecular structure

A piperidine ring with a tert-butyl(dimethyl)silyl group attached to the oxygen atom.

Protecting group

The tert-butyl(dimethyl)silyl group is commonly used as a protecting group in organic synthesis.

Reactivity

The protecting group can be removed under specific conditions to reveal a reactive hydroxyl group, allowing for further chemical reactions.

Versatility

2-([tert-butyl(dimethyl)silyl]oxymethyl)piperidine is a versatile chemical with potential applications in organic chemistry and drug discovery.

Use as intermediate or building block

The compound is likely used as an intermediate or building block in the synthesis of larger molecules.

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 3433-37-2 piperidin-2-ylmethanol 

Downstream Products

• 105706-75-0 1-benzyloxycarbonyl-2-hydroxymethylpiperidine 
• 1072344-54-7 tert-butyl ({1-[(2-cyanophenyl)sulfonyl]piperidin-2-yl}methoxy)acetate 
• 1072344-57-0 ((1-[(2-cyanophenyl)sulfonyl]piperidin-2-yl)methoxy)acetic acid 
• 1072344-41-2 benzyl 2-[(2-tert-butoxy-2-oxoethoxy)methyl]piperidine-1-carboxylate 
• 1031367-36-8 (2S)-2-({[tert-butyl(dimethyl)silyl]oxy}methyl)piperidine 
• 1031367-01-7 (2R)-2-({[tert-butyl(dimethyl)silyl]oxy}methyl)piperidine 
• 1346681-89-7 (R)-2-({[tert-butyl(dimethyl)silyl]oxy}methyl)-1-(3-mesitylpropanoyl)piperidine 
• 1072354-67-6 2-({[tert-butyl(dimethyl)silyl]oxy}methyl)-1-[(4-methoxy-2,6-dimethylphenyl)sulfonyl]piperidine 
• 1072344-35-4 benzyl 2-({[tert-butyl(dimethyl)silyl]oxy}methyl)piperidine-1-carboxylate 
• 625852-58-6 6,7,8,8a-tetrahydroindolizin-3(5H)-one 

Relevant articles and documents

THIOPHENE DERIVATIVE

The present invention provides a compound represented by the formula (I) or its salt, solvate, or physiologically functional derivative; and a pharmaceutical composition which is useful for treatment or prevention of conditions or disorders having sensitivity to selective androgen receptor modulation, the composition comprising the above-described compound; among others:

NEW BRADYKININ B1 ANTAGONISTS

The invention relates to compounds of formula (I), wherein R1 to R5 and X1 to X4, n and m have the meaning as cited in the description and the claims. Said compounds are useful as Bradykinin B1 antagonists. The

Carbamoylimidazolium salts as diversification reagents: An application to the synthesis of tertiary amides from carboxylic acids

An efficient method for the preparation of tertiary amides from carbamoylimidazolium salts and carboxylic acids is described. The transformation occurs at room temperature and under relatively mild conditions. The carbamoylimidazolium salts are obtained from the reaction of secondary amines with N,N′-carbonyldiimidazole, followed by methylation with methyl iodide. The utility of this reaction was demonstrated in the formation of Weinreb amides and in a short synthesis of fused bicyclic amides. The introduction of this reaction now permits carbamoylimidazolium salts to be utilized in the formation of tertiary amides, ureas, carbamates and thiocarbamates under a single set of conditions.