135944-05-7 Usage
Description
FMOC-ALPHA-METHYL-L-PHE, also known as Fmoc-alpha-methyl-L-phenylalanine, is a synthetic amino acid derivative that serves as a crucial building block in the field of peptide chemistry. It is characterized by its white solid appearance and is widely utilized in the synthesis of various biologically active peptides. The presence of the Fmoc (9-fluorenylmethoxycarbonyl) group provides protection to the amino acid during peptide synthesis, while the alpha-methyl substitution offers unique structural properties to the resulting peptides.
Uses
Used in Pharmaceutical Industry:
FMOC-ALPHA-METHYL-L-PHE is used as a synthetic building block for the development of peptidic partial agonists of the human neuromedin U receptor. These agonists exhibit enhanced serum stability, which is crucial for their potential therapeutic applications in treating various medical conditions related to the neuromedin U receptor.
Used in Research and Development:
In the field of research and development, FMOC-ALPHA-METHYL-L-PHE serves as a valuable reagent for the synthesis of novel peptides with specific biological activities. Its unique structural properties allow researchers to design and create peptides with tailored pharmacological profiles, which can be further explored for their potential therapeutic applications.
Used in Peptide Synthesis:
FMOC-ALPHA-METHYL-L-PHE is used as a protected amino acid in solid-phase peptide synthesis (SPPS). The Fmoc group provides temporary protection to the amino acid's side chain, allowing for the stepwise assembly of peptide chains without premature side reactions. This protection can be selectively removed during the synthesis process, enabling the addition of subsequent amino acids and the eventual formation of the desired peptide sequence.
Check Digit Verification of cas no
The CAS Registry Mumber 135944-05-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,5,9,4 and 4 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 135944-05:
(8*1)+(7*3)+(6*5)+(5*9)+(4*4)+(3*4)+(2*0)+(1*5)=137
137 % 10 = 7
So 135944-05-7 is a valid CAS Registry Number.
InChI:InChI=1/C25H23NO4/c1-25(23(27)28,15-17-9-3-2-4-10-17)26-24(29)30-16-22-20-13-7-5-11-18(20)19-12-6-8-14-21(19)22/h2-14,22H,15-16H2,1H3,(H,26,29)(H,27,28)/t25-/m0/s1
135944-05-7Relevant articles and documents
Thrombin receptor-activating peptides (TRAPs): Investigation of bioactive conformations via structure-activity, spectroscopic, and computational studies
Ceruso, Marco A.,McComsey, David F.,Leo, Gregory C.,Andrade-Gordon, Patricia,Addo, Michael F.,Scarborough, Robert M.,Oksenberg, Donna,Maryanoff, Bruce E.
, p. 2353 - 2371 (2007/10/03)
The thrombin receptor (PAR-1) is an unusual transmembrane G-protein coupled receptor in that it is activated by serine protease cleavage of its extracellular N-terminus to expose an agonist peptide ligand, which is tethered to the receptor itself. Synthet
