1359715-97-1

Basic information

• Product Name: 1-benzyl-3,4-diphenylisoquinoline
• Synonyms: 1-benzyl-3,4-diphenylisoquinoline
• CAS NO: 1359715-97-1
• Molecular Weight: 371.481
• Mol File: 1359715-97-1.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1-benzyl-3,4-diphenylisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-3,4-diphenylisoquinoline(1359715-97-1)
• EPA Substance Registry System: 1-benzyl-3,4-diphenylisoquinoline(1359715-97-1)

Safety Data

• Hazardous Substances Data: 1359715-97-1(Hazardous Substances Data)

Upstream product

• 1359715-87-9 2-iodophenyl benzyl ketone oxime 
• 501-65-5 diphenyl acetylene 
• 1359715-88-0 C₁₄H₁₂INO 
• 430429-42-8 1-(2-iodophenyl)-2-phenyl-1-ethanone 
• 451-40-1 phenyl benzyl ketone 
• 1172591-90-0 1-benzyl-2-(phenylethynyl)benzene 
• 100-47-0 benzonitrile 
• 35444-93-0 ortho-benzyliodobenzene 
• 536-74-3 phenylacetylene 
• 31839-62-0 2,2-dimethyl-4,5-diphenyl-2H-imidazole 
• 5171-96-0 (1,2-diphenylethylidene)hydrazine 
• 40145-79-7 1,2-diphenyldiazoethane 

Relevant articles and documents

Synthesis of α-Ketone-isoquinoline Derivatives via Tandem Ruthenium(II)-Catalyzed C-H Activation and Annulation

A new ruthenium(II)-catalyzed tandem C-H activation/cyclization/hydrolysis cascade process of 2H-imidazoles and alkynes for facile and regioselective access to α-ketone-isoquinolines has been successfully developed. 2H-Imidazole as the novel traceless directing group has been well applied in this paper. The protocol features mild reaction conditions and easily accessible starting materials, and α-ketone-isoquinolines could be applied to further construct more complex heterocyclic compounds.

Synthesis of 1-Benzyl-, 1-Alkoxyl-, and 1-Aminoisoquinolines via Rhodium(III)-Catalyzed Aryl C-H Activation and Alkyne Annulation

One-pot syntheses of 1-benzyl-, 1-Alkoxyl-, and 1-Alkylamino-isoquinolines through automatic directing group (DGauto)-Assisted, rhodium(III)-catalyzed aryl C-H activation and annulation with internal alkynes were developed. The reactions affording 1-benzylisoquinolines involve a cascade oximation of diarylacetylenes with hydroxylamine, forming aryl benzyl ketone oxime, and oxime-Assisted rhodium(III)-catalyzed aryl C-H activation and followed annulation with another molecule of diarylacetylene in a one-pot manner. The formation of 1-Alkoxyl/amino isoquinolines includes the addition of nucleophilic alcohols or amines to aryl nitriles, imine-Assisted rhodium-catalyzed aryl C-H activation, and subsequent alkyne annulation.

Easy Access to 1-Amino and 1-Carbon Substituted Isoquinolines via Cobalt-Catalyzed C - H/N - O Bond Activation

A green atom-economical method for the synthesis of highly functionalized 1-amino and 1-carbon substituted isoquinolines from the reaction of N′-hydroxybenzimidamides and aryl ketoximes, respectively, with alkynes via pentamethylcyclopentadienylcobalt(III)-catalyzed C - H/N - O bond activation is described. The external oxidant-free annulation reaction uses the =NOH moiety in N′-hydroxybenzimidamides or N-aromatic ketone oximes as the directing group and internal oxidant. This first row transition metal-catalyzed annulation serves as an efficient alternative for the synthesis of isoquinolines, as water is the only by-product and expensive noble metals such as rhodium(III), iridium(III), palladium(II), and ruthenium(II) are not required. The reaction proceeds via C - H activation, alkyne insertion, reductive elimination, and N - O activation.