1359939-99-3Relevant articles and documents
Synthesis of new transition metal complexes of 1H-perimidine derivatives having antimicrobial and anti-inflammatory activities
Bassyouni, Fatma A.,Abu-Bakr, Sherifa M.,Hegab, Khaled H.,El-Eraky, Wafaa,El Beih, Ahmed A.,Abdel, Mohamed E.
, p. 1527 - 1550 (2012/11/13)
New series of 1H-perimidine-2-thiol derivatives and (2-substituted- 1Hperimidin- 1-yl)ethane-1,2-dione derivatives and their ligands (C 24H14N4S2O2) H 2L1 and (C26H18N4S 2O2) H2L2 have been synthesized with transition metal ions, e.g., Copper (II), Silver (I), Cobalt (II) and Ruthenium (III) were prepared and evaluated for their antimicrobial, analgesic and anti-inflammatory activities. The synthesized compounds and their complexes were characterized by elemental analysis, 1H NMR, IR, MS, molar conductance, thermal gravimetric analysis and electronic spectra. All results revealed that compounds 3 and 13 exhibited high inhibitory effects against some bacterial strains by the disc diffusion method. On the other hand, compounds 2, 3, 7 and 12 displayed potent anti-inflammatory activity. Springer Science+Business Media B.V. 2012.
