1360059-88-6

Basic information

• Product Name: C₄₆H₇₂N₂O₁₂
• Synonyms: C₄₆H₇₂N₂O₁₂
• CAS NO: 1360059-88-6
• Molecular Weight: 845.084
• Mol File: 1360059-88-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₄₆H₇₂N₂O₁₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₆H₇₂N₂O₁₂(1360059-88-6)
• EPA Substance Registry System: C₄₆H₇₂N₂O₁₂(1360059-88-6)

Safety Data

• Hazardous Substances Data: 1360059-88-6(Hazardous Substances Data)

Upstream product

• 791845-56-2 2',4-O-bis(trimethylsilyl)-6-O-methylerythromycin A 9-(E)-O-(1-isopropoxycyclohexyl)-oxime 
• 1360059-73-9 2'-O-trimethylsilyl-3-O-descladinosyl-6-O-methylerythromycin A 9-(E)-O-(1-isopropoxycyclohexyl)oxime 
• 1360059-74-0 2'-O-trimethylsilyl-3-O-descladinosyl-3-O-allyl-6-O-methylerythromycin A 9-(E)-O-(1-isopropoxycyclohexyl)oxime 
• 1360059-75-1 3-O-descladinosyl-3-O-allyl-6-O-methylerythromycin A 9-(E)-oxime 
• 1360059-82-0 2'-O-acetyl-3-O-descladinosyl-3-O-allyl-6-O-methylerythromycin A 9-(E)-O-acetyl-oxime 
• 1360059-83-1 2'-O-acetyl-3-O-descladinosyl-3-O-allyl-6-O-methylerythromycin A 9-(E)-O-acetyloxime 11,12-cyclic carbonate 
• 1585-16-6 2-chloromethyl-1,3,5-trimethylbenzene 
• 561327-03-5 (E)-5-O-desosaminyl-6-O-methylerythronolide A 9-oxime 

Downstream Products

• 1360059-89-7 3-O-descladinosyl-3-O-[3-(5-pyrimidyl)-(E)-prop-2-enyl]-6-O-methylerythromycin A 9-(E)-O-(2,4,6-trimethylbenzyl)oxime 11,12-cyclic carbonate 

Relevant articles and documents

Structure-activity relationships of novel alkylides: 3-O-Arylalkyl clarithromycin derivatives with improved antibacterial activities

A series of novel alkylides, possessing 3-O-arylalkyl group instead of 3-O-cladinose, were designed, synthesized and evaluated for in vitro antibacterial activities. The increased potency clearly ranked by the order of 3-O-(3-aryl-2-propargyl), 3-O-(3-aryl-E-prop-2-enyl), 3-O-(3-aryl-propyl), and 3-O-(3-aryl-Z-prop-1-enyl) groups. Some alkylides, exemplified by 7a, 10a, 21, 22, 26, 27 and 33, showed improved activities against inducible MLSB resistance and efflux resistance compared to the second-generation macrolides. Among them, 26 possessed comparable activities against erythromycin-susceptible Staphylococcus aureus, Streptococcus pneumoniae and Streptococcus pyogenes (MICs of 0.016-0.5 μg/mL). Moreover, 26 displayed dramatically enhanced potency against both efflux resistant and inducibly MLSB resistant strains (MICs of 0.125-0.5 μg/mL) resistant to clarithromycin and azithromycin (MICs of 1- >254 μg/mL), independent of methicillin-susceptible and methicillin-resistant phenotypes.